| TSIVGOULIS, Georgios, Duncan WILSON, Aristeidis H. KATSANOS, Joao SARGENTO-FREITAS, Claudia MARQUES-MATOS, Elsa AZEVEDO, Tomohide ADACHI, Christian BRELIE, Yoshifusa AIZAWA, Hiroshi ABE, Hirofumi TOMITA, Ken OKUMURA, Joji HAGII, David J. SEIFFGE, Vasileios-Arsenios LIOUTAS, Christopher TRAENKA, Panayiotis VARELAS, Ghazala BASIR, Christos KROGIAS, Jan C. PURRUCKER, Vijay K. SHARMA, Timolaos RIZOS, Robert MIKULÍK, Oluwaseun A. SOBOWALE, Kristian BARLINN, Hanne SALLINEN, Nitin GOYAL, Shin-Joe YEH, Theodore KARAPANAYIOTIDES, Teddy Y. WU, Konstantinos VADIKOLIAS, Marc FERRIGNO, Georgios HADJIGEORGIOU, Rik HOUBEN, Sotirios GIANNOPOULOS, Floris H. B. M. SCHREUDER, Jason J. CHANG, Luke A. PERRY, Maximilian MEHDORN, Joao-Pedro MARTO, Joao PINHO, Jun TANAKA, Marion BOULANGER, Rustam Al-Shahi SALMAN, Hans R. JAEGER, Clare SHAKESHAFT, Yusuke YAKUSHIJI, Philip M. C. CHOI, Julie STAALS, Charlotte CORDONNIER, Jiann-Shing JENG, Roland VELTKAMP, Dar DOWLATSHAHI, Stefan T. ENGELTER, Adrian R. PARRY-JONES, Atte MERETOJA, Panayiotis D. MITSIAS, Andrei V. ALEXANDROV, Gareth AMBLER and David J. WERRING. Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage. Annals of neurology. Hoboken: John Wiley & Sons, 2018, vol. 84, No 5, p. 694-704. ISSN 0364-5134. Available from: https://dx.doi.org/10.1002/ana.25342. |
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@article{1484299,
author = {Tsivgoulis, Georgios and Wilson, Duncan and Katsanos, Aristeidis H. and SargentoandFreitas, Joao and MarquesandMatos, Claudia and Azevedo, Elsa and Adachi, Tomohide and Brelie, Christian and Aizawa, Yoshifusa and Abe, Hiroshi and Tomita, Hirofumi and Okumura, Ken and Hagii, Joji and Seiffge, David J. and Lioutas, VasileiosandArsenios and Traenka, Christopher and Varelas, Panayiotis and Basir, Ghazala and Krogias, Christos and Purrucker, Jan C. and Sharma, Vijay K. and Rizos, Timolaos and Mikulík, Robert and Sobowale, Oluwaseun A. and Barlinn, Kristian and Sallinen, Hanne and Goyal, Nitin and Yeh, ShinandJoe and Karapanayiotides, Theodore and Wu, Teddy Y. and Vadikolias, Konstantinos and Ferrigno, Marc and Hadjigeorgiou, Georgios and Houben, Rik and Giannopoulos, Sotirios and Schreuder, Floris H. B. M. and Chang, Jason J. and Perry, Luke A. and Mehdorn, Maximilian and Marto, JoaoandPedro and Pinho, Joao and Tanaka, Jun and Boulanger, Marion and Salman, Rustam AlandShahi and Jaeger, Hans R. and Shakeshaft, Clare and Yakushiji, Yusuke and Choi, Philip M. C. and Staals, Julie and Cordonnier, Charlotte and Jeng, JiannandShing and Veltkamp, Roland and Dowlatshahi, Dar and Engelter, Stefan T. and ParryandJones, Adrian R. and Meretoja, Atte and Mitsias, Panayiotis D. and Alexandrov, Andrei V. and Ambler, Gareth and Werring, David J.},
article_location = {Hoboken},
article_number = {5},
doi = {http://dx.doi.org/10.1002/ana.25342},
keywords = {vitamin K antagonists; intracerebral hemorrhage},
language = {eng},
issn = {0364-5134},
journal = {Annals of neurology},
title = {Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage},
volume = {84},
year = {2018}
}
TY - JOUR
ID - 1484299
AU - Tsivgoulis, Georgios - Wilson, Duncan - Katsanos, Aristeidis H. - Sargento-Freitas, Joao - Marques-Matos, Claudia - Azevedo, Elsa - Adachi, Tomohide - Brelie, Christian - Aizawa, Yoshifusa - Abe, Hiroshi - Tomita, Hirofumi - Okumura, Ken - Hagii, Joji - Seiffge, David J. - Lioutas, Vasileios-Arsenios - Traenka, Christopher - Varelas, Panayiotis - Basir, Ghazala - Krogias, Christos - Purrucker, Jan C. - Sharma, Vijay K. - Rizos, Timolaos - Mikulík, Robert - Sobowale, Oluwaseun A. - Barlinn, Kristian - Sallinen, Hanne - Goyal, Nitin - Yeh, Shin-Joe - Karapanayiotides, Theodore - Wu, Teddy Y. - Vadikolias, Konstantinos - Ferrigno, Marc - Hadjigeorgiou, Georgios - Houben, Rik - Giannopoulos, Sotirios - Schreuder, Floris H. B. M. - Chang, Jason J. - Perry, Luke A. - Mehdorn, Maximilian - Marto, Joao-Pedro - Pinho, Joao - Tanaka, Jun - Boulanger, Marion - Salman, Rustam Al-Shahi - Jaeger, Hans R. - Shakeshaft, Clare - Yakushiji, Yusuke - Choi, Philip M. C. - Staals, Julie - Cordonnier, Charlotte - Jeng, Jiann-Shing - Veltkamp, Roland - Dowlatshahi, Dar - Engelter, Stefan T. - Parry-Jones, Adrian R. - Meretoja, Atte - Mitsias, Panayiotis D. - Alexandrov, Andrei V. - Ambler, Gareth - Werring, David J.
PY - 2018
TI - Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage
JF - Annals of neurology
VL - 84
IS - 5
SP - 694-704
EP - 694-704
PB - John Wiley & Sons
SN - 03645134
KW - vitamin K antagonists
KW - intracerebral hemorrhage
N2 - Objective Methods Whether intracerebral hemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin K antagonists (VKA-ICH) is uncertain. We performed a systematic review and individual patient data meta-analysis of cohort studies comparing clinical and radiological outcomes between NOAC-ICH and VKA-ICH patients. The primary outcome measure was 30-day all-cause mortality. All outcomes were assessed in multivariate regression analyses adjusted for age, sex, ICH location, and intraventricular hemorrhage extension. Results Interpretation We included 7 eligible studies comprising 219 NOAC-ICH and 831 VKA-ICH patients (mean age = 77 years, 52.5% females). The 30-day mortality was similar between NOAC-ICH and VKA-ICH (24.3% vs 26.5%; hazard ratio = 0.94, 95% confidence interval [CI] = 0.67-1.31). However, in multivariate analyses adjusting for potential confounders, NOAC-ICH was associated with lower admission National Institutes of Health Stroke Scale (NIHSS) score (linear regression coefficient = -2.83, 95% CI = -5.28 to -0.38), lower likelihood of severe stroke (NIHSS > 10 points) on admission (odds ratio [OR] = 0.50, 95% CI = 0.30-0.84), and smaller baseline hematoma volume (linear regression coefficient = -0.24, 95% CI = -0.47 to -0.16). The two groups did not differ in the likelihood of baseline hematoma volume < 30cm(3) (OR = 1.14, 95% CI = 0.81-1.62), hematoma expansion (OR = 0.97, 95% CI = 0.63-1.48), in-hospital mortality (OR = 0.73, 95% CI = 0.49-1.11), functional status at discharge (common OR = 0.78, 95% CI = 0.57-1.07), or functional status at 3 months (common OR = 1.03, 95% CI = 0.75-1.43). Although functional outcome at discharge, 1 month, or 3 months was comparable after NOAC-ICH and VKA-ICH, patients with NOAC-ICH had smaller baseline hematoma volumes and less severe acute stroke syndromes. Ann Neurol 2018;84:702-712
ER -
TSIVGOULIS, Georgios, Duncan WILSON, Aristeidis H. KATSANOS, Joao SARGENTO-FREITAS, Claudia MARQUES-MATOS, Elsa AZEVEDO, Tomohide ADACHI, Christian BRELIE, Yoshifusa AIZAWA, Hiroshi ABE, Hirofumi TOMITA, Ken OKUMURA, Joji HAGII, David J. SEIFFGE, Vasileios-Arsenios LIOUTAS, Christopher TRAENKA, Panayiotis VARELAS, Ghazala BASIR, Christos KROGIAS, Jan C. PURRUCKER, Vijay K. SHARMA, Timolaos RIZOS, Robert MIKULÍK, Oluwaseun A. SOBOWALE, Kristian BARLINN, Hanne SALLINEN, Nitin GOYAL, Shin-Joe YEH, Theodore KARAPANAYIOTIDES, Teddy Y. WU, Konstantinos VADIKOLIAS, Marc FERRIGNO, Georgios HADJIGEORGIOU, Rik HOUBEN, Sotirios GIANNOPOULOS, Floris H. B. M. SCHREUDER, Jason J. CHANG, Luke A. PERRY, Maximilian MEHDORN, Joao-Pedro MARTO, Joao PINHO, Jun TANAKA, Marion BOULANGER, Rustam Al-Shahi SALMAN, Hans R. JAEGER, Clare SHAKESHAFT, Yusuke YAKUSHIJI, Philip M. C. CHOI, Julie STAALS, Charlotte CORDONNIER, Jiann-Shing JENG, Roland VELTKAMP, Dar DOWLATSHAHI, Stefan T. ENGELTER, Adrian R. PARRY-JONES, Atte MERETOJA, Panayiotis D. MITSIAS, Andrei V. ALEXANDROV, Gareth AMBLER and David J. WERRING. Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage. \textit{Annals of neurology}. Hoboken: John Wiley \&{} Sons, 2018, vol.~84, No~5, p.~694-704. ISSN~0364-5134. Available from: https://dx.doi.org/10.1002/ana.25342.
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