White matter alterations in Parkinson's disease with normal
cognition precede grey matter atrophy

J 2018

White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy

REKTOR, Ivan, Alena SVÁTKOVÁ, Lubomír VOJTÍŠEK, Ilona ZIKMUNDOVÁ, Jiří VANÍČEK et. al.

Basic information

Original name

White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy

Authors

REKTOR, Ivan (203 Czech Republic, guarantor, belonging to the institution), Alena SVÁTKOVÁ (703 Slovakia, belonging to the institution), Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Ilona ZIKMUNDOVÁ (203 Czech Republic, belonging to the institution), Jiří VANÍČEK (203 Czech Republic, belonging to the institution), András KIRÁLY (348 Hungary, belonging to the institution) and Nikoletta SZABÓ (348 Hungary, belonging to the institution)

Edition

Plos one, San Francisco, Public Library of Science, 2018, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.776

RIV identification code

RIV/00216224:14740/18:00105511

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1371/journal.pone.0187939

UT WoS

000419403800009

Keywords in English

VOXEL-BASED MORPHOMETRY; PROGRESSIVE SUPRANUCLEAR PALSY; MULTIPLE SYSTEM ATROPHY; SUBJECT DIFFUSION DATA; SPATIAL STATISTICS; BRAIN IMAGES; IMPAIRMENT; GRAY; TENSOR; CONNECTIVITY

Abstract

V originále

Introduction While progressive MRI brain changes characterize advanced Parkinson's disease (PD), little has been discovered about structural alterations in the earliest phase of the disease, i.e. in patients with motor symptoms and with normal cognition. Our study aimed to detect grey matter (GM) and white matter (WM) changes in PD patients without cognitive impairment. Methods Twenty PD patients and twenty-one healthy controls (HC) were tested for attention, executive function, working memory, and visuospatial and language domains. High-resolution T1-weighted and 60 directional diffusion-weighted 3T MRI images were acquired. The cortical, deep GM and WM volumes and density, as well as the diffusion properties of WM, were calculated. Analyses were repeated on data flipped to the side of the disease origin. Results PD patients did not show any significant differences from HC in cognitive functioning or in brain volumes. Decreased GM intensity was found in the left superior parietal lobe in the right (p<0.02) and left (p<0.01) flipped data. The analysis of original, un-flipped data demonstrated elevated axial diffusivity (p<0.01) in the superior and anterior corona radiata, internal capsule, and external capsule in the left hemisphere of PD relative to HC, while higher mean and radial diffusivity were discovered in the right (p<0.02 and p<0.03, respectively) and left (p<0.02 and p<0.02, respectively) in the fronto-temporal WMutilizing flipped data. Conclusions PD patients without cognitive impairment and GM atrophy demonstrated widespread alterations of WM microstructure. Thus, WM impairment in PD might be a sensitive sign preceding the neuronal loss in associated GM regions.

Links

LM2015062, research and development project

Name: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministry of Education, Youth and Sports of the CR

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

691110, interní kód MU

Name: Advanced MR methods for characterization of microstructural brain damage (MICROBRADAM) (Acronym: MICROBRADAM)

Investor: European Union, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

Citovat

REKTOR, Ivan, Alena SVÁTKOVÁ, Lubomír VOJTÍŠEK, Ilona ZIKMUNDOVÁ, Jiří VANÍČEK, András KIRÁLY and Nikoletta SZABÓ. White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy. Plos one. San Francisco: Public Library of Science, 2018, vol. 13, No 1, p. 1-15. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0187939.

@article{1486798,
   author = {Rektor, Ivan and Svátková, Alena and Vojtíšek, Lubomír and Zikmundová, Ilona and Vaníček, Jiří and Király, András and Szabó, Nikoletta},
   article_location = {San Francisco},
   article_number = {1},
   doi = {http://dx.doi.org/10.1371/journal.pone.0187939},
   keywords = {VOXEL-BASED MORPHOMETRY; PROGRESSIVE SUPRANUCLEAR PALSY; MULTIPLE SYSTEM ATROPHY; SUBJECT DIFFUSION DATA; SPATIAL STATISTICS; BRAIN IMAGES; IMPAIRMENT; GRAY; TENSOR; CONNECTIVITY},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy},
   url = {https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0187939&type=printable},
   volume = {13},
   year = {2018}
}

TY  - JOUR
ID  - 1486798
AU  - Rektor, Ivan - Svátková, Alena - Vojtíšek, Lubomír - Zikmundová, Ilona - Vaníček, Jiří - Király, András - Szabó, Nikoletta
PY  - 2018
TI  - White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy
JF  - Plos one
VL  - 13
IS  - 1
SP  - 1-15
EP  - 1-15
PB  - Public Library of Science
SN  - 19326203
KW  - VOXEL-BASED MORPHOMETRY
KW  - PROGRESSIVE SUPRANUCLEAR PALSY
KW  - MULTIPLE SYSTEM ATROPHY
KW  - SUBJECT DIFFUSION DATA
KW  - SPATIAL STATISTICS
KW  - BRAIN IMAGES
KW  - IMPAIRMENT
KW  - GRAY
KW  - TENSOR
KW  - CONNECTIVITY
UR  - https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0187939&type=printable
N2  - Introduction While progressive MRI brain changes characterize advanced Parkinson's disease (PD), little has been discovered about structural alterations in the earliest phase of the disease, i.e. in patients with motor symptoms and with normal cognition. Our study aimed to detect grey matter (GM) and white matter (WM) changes in PD patients without cognitive impairment. Methods Twenty PD patients and twenty-one healthy controls (HC) were tested for attention, executive function, working memory, and visuospatial and language domains. High-resolution T1-weighted and 60 directional diffusion-weighted 3T MRI images were acquired. The cortical, deep GM and WM volumes and density, as well as the diffusion properties of WM, were calculated. Analyses were repeated on data flipped to the side of the disease origin. Results PD patients did not show any significant differences from HC in cognitive functioning or in brain volumes. Decreased GM intensity was found in the left superior parietal lobe in the right (p<0.02) and left (p<0.01) flipped data. The analysis of original, un-flipped data demonstrated elevated axial diffusivity (p<0.01) in the superior and anterior corona radiata, internal capsule, and external capsule in the left hemisphere of PD relative to HC, while higher mean and radial diffusivity were discovered in the right (p<0.02 and p<0.03, respectively) and left (p<0.02 and p<0.02, respectively) in the fronto-temporal WMutilizing flipped data. Conclusions PD patients without cognitive impairment and GM atrophy demonstrated widespread alterations of WM microstructure. Thus, WM impairment in PD might be a sensitive sign preceding the neuronal loss in associated GM regions.
ER  -

REKTOR, Ivan, Alena SVÁTKOVÁ, Lubomír VOJTÍŠEK, Ilona ZIKMUNDOVÁ, Jiří VANÍČEK, András KIRÁLY and Nikoletta SZABÓ. White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy. \textit{Plos one}. San Francisco: Public Library of Science, 2018, vol.~13, No~1, p.~1-15. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0187939.

Detailed Information on Publication Record