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@article{1486798,
author = {Rektor, Ivan and Svátková, Alena and Vojtíšek, Lubomír and Zikmundová, Ilona and Vaníček, Jiří and Király, András and Szabó, Nikoletta},
article_location = {San Francisco},
article_number = {1},
doi = {http://dx.doi.org/10.1371/journal.pone.0187939},
keywords = {VOXEL-BASED MORPHOMETRY; PROGRESSIVE SUPRANUCLEAR PALSY; MULTIPLE SYSTEM ATROPHY; SUBJECT DIFFUSION DATA; SPATIAL STATISTICS; BRAIN IMAGES; IMPAIRMENT; GRAY; TENSOR; CONNECTIVITY},
language = {eng},
issn = {1932-6203},
journal = {Plos one},
title = {White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy},
url = {https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0187939&type=printable},
volume = {13},
year = {2018}
}
TY - JOUR
ID - 1486798
AU - Rektor, Ivan - Svátková, Alena - Vojtíšek, Lubomír - Zikmundová, Ilona - Vaníček, Jiří - Király, András - Szabó, Nikoletta
PY - 2018
TI - White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy
JF - Plos one
VL - 13
IS - 1
SP - 1-15
EP - 1-15
PB - Public Library of Science
SN - 19326203
KW - VOXEL-BASED MORPHOMETRY
KW - PROGRESSIVE SUPRANUCLEAR PALSY
KW - MULTIPLE SYSTEM ATROPHY
KW - SUBJECT DIFFUSION DATA
KW - SPATIAL STATISTICS
KW - BRAIN IMAGES
KW - IMPAIRMENT
KW - GRAY
KW - TENSOR
KW - CONNECTIVITY
UR - https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0187939&type=printable
N2 - Introduction While progressive MRI brain changes characterize advanced Parkinson's disease (PD), little has been discovered about structural alterations in the earliest phase of the disease, i.e. in patients with motor symptoms and with normal cognition. Our study aimed to detect grey matter (GM) and white matter (WM) changes in PD patients without cognitive impairment. Methods Twenty PD patients and twenty-one healthy controls (HC) were tested for attention, executive function, working memory, and visuospatial and language domains. High-resolution T1-weighted and 60 directional diffusion-weighted 3T MRI images were acquired. The cortical, deep GM and WM volumes and density, as well as the diffusion properties of WM, were calculated. Analyses were repeated on data flipped to the side of the disease origin. Results PD patients did not show any significant differences from HC in cognitive functioning or in brain volumes. Decreased GM intensity was found in the left superior parietal lobe in the right (p<0.02) and left (p<0.01) flipped data. The analysis of original, un-flipped data demonstrated elevated axial diffusivity (p<0.01) in the superior and anterior corona radiata, internal capsule, and external capsule in the left hemisphere of PD relative to HC, while higher mean and radial diffusivity were discovered in the right (p<0.02 and p<0.03, respectively) and left (p<0.02 and p<0.02, respectively) in the fronto-temporal WMutilizing flipped data. Conclusions PD patients without cognitive impairment and GM atrophy demonstrated widespread alterations of WM microstructure. Thus, WM impairment in PD might be a sensitive sign preceding the neuronal loss in associated GM regions.
ER -
REKTOR, Ivan, Alena SVÁTKOVÁ, Lubomír VOJTÍŠEK, Ilona ZIKMUNDOVÁ, Jiří VANÍČEK, András KIRÁLY and Nikoletta SZABÓ. White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy. \textit{Plos one}. San Francisco: Public Library of Science, vol.~13, No~1, p.~1-15. ISSN~1932-6203. doi:10.1371/journal.pone.0187939. 2018.
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