Hippocampal involvement in nonpathological deja vu: Subfield
vulnerability rather than temporal lobe epilepsy equivalent

J 2018

Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent

PEŠLOVÁ, Eva, Radek MAREČEK, Daniel Joel SHAW, Tomáš KAŠPÁREK, Martin PAIL et. al.

Basic information

Original name

Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent

Authors

PEŠLOVÁ, Eva (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Daniel Joel SHAW (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution), Martin PAIL (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, guarantor, belonging to the institution)

Edition

Brain and Behavior, Hoboken, Wiley, 2018, 2162-3279

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.072

RIV identification code

RIV/00216224:14110/18:00105516

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/brb3.996

UT WoS

000438495400021

Keywords in English

deja vu; hippocampal subfields; hippocampal vulnerability; mesial temporal lobe epilepsy; schizophrenia

Abstract

V originále

Introduction: Morphological correlates of nonpathological deja vu (DV) have been identified recently within the human brain. Significantly reduced gray matter volume (GMV) within a set of cortical and subcortical regions reported in subjects experiencing DV seems to mirror the distribution of GMV reduction in mesial temporal lobe epilepsy (MTLE) patients but vary in terms of the hippocampus. Another condition associated with hippocampal GMV reduction and DV alike disturbance in memory processing is schizophrenia (SCH). Here, we tested the hypothesis that hippocampal involvement in nonpathological DV resembles more closely the pattern of GMV decrease observed in MTLE compared with that occurring in SCH. Methods: Using automated segmentation of the MRI data we compared the medians of GMV within 12 specific hippocampal subfields in healthy individuals that do (DV+; N = 87) and do not report deja vu experience (DV-; N = 26), and patients with MTLE (N = 47) and SCH (N = 29). By Pearson correlation, we then evaluated the similarity of MTLE and SCH groups to DV+ group with respect to spatial distribution of GMV deviation from DV- group. Results: Significant GMV decrease was found in MTLE group in most of the subfields. There were just trends in the hippocampal GMV decrease found in DV+ or SCH groups. Concerning the spatial distribution of GMV decrease, we revealed statistically significant correlation for the left hippocampus for SCH vs DV+, Otherwise there was no statistically significant correlation. Conclusions: Our findings reveal structural features of hippocampal involvement in nonpathological DV, MTLE, and SCH. Despite our expectations, the pattern of GMV reduction in the DV+ relative to the DV- group does not resemble the pattern observed in MTLE any more than that observed in SCH. The highly similar patterns of the three clinical groups rather suggest an increased vulnerability of certain hippocampal subfields; namely, Cornu Ammonis (CA)4, CA3, dentate gyrus granular cell layer (GC-DG), hippocampal-amygdaloid transition area (HATA) and subiculum.

Links

LM2015062, research and development project

Name: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministry of Education, Youth and Sports of the CR

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

PEŠLOVÁ, Eva, Radek MAREČEK, Daniel Joel SHAW, Tomáš KAŠPÁREK, Martin PAIL and Milan BRÁZDIL. Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent. Brain and Behavior. Hoboken: Wiley, 2018, vol. 8, No 7, p. 1-9. ISSN 2162-3279. Available from: https://dx.doi.org/10.1002/brb3.996.

@article{1486822,
   author = {Pešlová, Eva and Mareček, Radek and Shaw, Daniel Joel and Kašpárek, Tomáš and Pail, Martin and Brázdil, Milan},
   article_location = {Hoboken},
   article_number = {7},
   doi = {http://dx.doi.org/10.1002/brb3.996},
   keywords = {deja vu; hippocampal subfields; hippocampal vulnerability; mesial temporal lobe epilepsy; schizophrenia},
   language = {eng},
   issn = {2162-3279},
   journal = {Brain and Behavior},
   title = {Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1486822
AU  - Pešlová, Eva - Mareček, Radek - Shaw, Daniel Joel - Kašpárek, Tomáš - Pail, Martin - Brázdil, Milan
PY  - 2018
TI  - Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent
JF  - Brain and Behavior
VL  - 8
IS  - 7
SP  - 1-9
EP  - 1-9
PB  - Wiley
SN  - 21623279
KW  - deja vu
KW  - hippocampal subfields
KW  - hippocampal vulnerability
KW  - mesial temporal lobe epilepsy
KW  - schizophrenia
N2  - Introduction: Morphological correlates of nonpathological deja vu (DV) have been identified recently within the human brain. Significantly reduced gray matter volume (GMV) within a set of cortical and subcortical regions reported in subjects experiencing DV seems to mirror the distribution of GMV reduction in mesial temporal lobe epilepsy (MTLE) patients but vary in terms of the hippocampus. Another condition associated with hippocampal GMV reduction and DV alike disturbance in memory processing is schizophrenia (SCH). Here, we tested the hypothesis that hippocampal involvement in nonpathological DV resembles more closely the pattern of GMV decrease observed in MTLE compared with that occurring in SCH. Methods: Using automated segmentation of the MRI data we compared the medians of GMV within 12 specific hippocampal subfields in healthy individuals that do (DV+; N = 87) and do not report deja vu experience (DV-; N = 26), and patients with MTLE (N = 47) and SCH (N = 29). By Pearson correlation, we then evaluated the similarity of MTLE and SCH groups to DV+ group with respect to spatial distribution of GMV deviation from DV- group. Results: Significant GMV decrease was found in MTLE group in most of the subfields. There were just trends in the hippocampal GMV decrease found in DV+ or SCH groups. Concerning the spatial distribution of GMV decrease, we revealed statistically significant correlation for the left hippocampus for SCH vs DV+, Otherwise there was no statistically significant correlation. Conclusions: Our findings reveal structural features of hippocampal involvement in nonpathological DV, MTLE, and SCH. Despite our expectations, the pattern of GMV reduction in the DV+ relative to the DV- group does not resemble the pattern observed in MTLE any more than that observed in SCH. The highly similar patterns of the three clinical groups rather suggest an increased vulnerability of certain hippocampal subfields; namely, Cornu Ammonis (CA)4, CA3, dentate gyrus granular cell layer (GC-DG), hippocampal-amygdaloid transition area (HATA) and subiculum.
ER  -

PEŠLOVÁ, Eva, Radek MAREČEK, Daniel Joel SHAW, Tomáš KAŠPÁREK, Martin PAIL and Milan BRÁZDIL. Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent. \textit{Brain and Behavior}. Hoboken: Wiley, 2018, vol.~8, No~7, p.~1-9. ISSN~2162-3279. Available from: https://dx.doi.org/10.1002/brb3.996.

Detailed Information on Publication Record