| LEHTO, Lauri J., Pavel FILIP, Hanne LAAKSO, Alejandra SIERRA, Julia P. SLOPSEMA, Matthew D. JOHNSON, Lynn E. EBERLY, Walter C. LOW, Olli GROHN, Heikki TANILA, Silvia MANGIA and Shalom MICHAEL. Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex. Frontiers in Neuroscience. Lausanne: Frontiers Media S.A., 2018, vol. 12, No 899, p. 1-10. ISSN 1662-453X. Available from: https://dx.doi.org/10.3389/fnins.2018.00899. |
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@article{1486849,
author = {Lehto, Lauri J. and Filip, Pavel and Laakso, Hanne and Sierra, Alejandra and Slopsema, Julia P. and Johnson, Matthew D. and Eberly, Lynn E. and Low, Walter C. and Grohn, Olli and Tanila, Heikki and Mangia, Silvia and Michael, Shalom},
article_location = {Lausanne},
article_number = {899},
doi = {http://dx.doi.org/10.3389/fnins.2018.00899},
keywords = {deep brain stimulation; infralimbic cortex; fMRI; orientation selective; depression},
language = {eng},
issn = {1662-453X},
journal = {Frontiers in Neuroscience},
title = {Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex},
volume = {12},
year = {2018}
}
TY - JOUR
ID - 1486849
AU - Lehto, Lauri J. - Filip, Pavel - Laakso, Hanne - Sierra, Alejandra - Slopsema, Julia P. - Johnson, Matthew D. - Eberly, Lynn E. - Low, Walter C. - Grohn, Olli - Tanila, Heikki - Mangia, Silvia - Michael, Shalom
PY - 2018
TI - Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex
JF - Frontiers in Neuroscience
VL - 12
IS - 899
SP - 1-10
EP - 1-10
PB - Frontiers Media S.A.
SN - 1662453X
KW - deep brain stimulation
KW - infralimbic cortex
KW - fMRI
KW - orientation selective
KW - depression
N2 - Previous studies that focused on treating major depressive disorder with conventional deep brain stimulation (DBS) paradigms produced inconsistent results. In this proof-of-concept preclinical study in rats (n = 8), we used novel paradigms of orientation selective DBS for stimulating the complex circuitry crossing the infralimbic cortex, an area considered analogous to human subgenual cingulate cortex. Using functional MRI at 9.4 T, we monitored whole brain responses to varying the electrical field orientation of DBS within the infralimbic cortex. Substantial alterations of functional MRI responses in the amygdala, a major node connected to the infralimbic cortex implicated in the pathophysiology of depression, were observed. As expected, the activation cluster near the electrode was insensitive to the changes of the stimulation orientation. Hence, our findings substantiate the ability of orientation selective stimulation (OSS) to recruit neuronal pathways of distinct orientations relative to the position of the electrode, even in complex circuits such as those involved in major depressive disorder. We conclude that OSS is a promising approach for stimulating brain areas that inherently require individualisation of the treatment approach.
ER -
LEHTO, Lauri J., Pavel FILIP, Hanne LAAKSO, Alejandra SIERRA, Julia P. SLOPSEMA, Matthew D. JOHNSON, Lynn E. EBERLY, Walter C. LOW, Olli GROHN, Heikki TANILA, Silvia MANGIA and Shalom MICHAEL. Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex. \textit{Frontiers in Neuroscience}. Lausanne: Frontiers Media S.A., 2018, vol.~12, No~899, p.~1-10. ISSN~1662-453X. Available from: https://dx.doi.org/10.3389/fnins.2018.00899.
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