Cardiac sigma receptors - An update

STRAČINA, Tibor and Marie NOVÁKOVÁ. Cardiac sigma receptors - An update. Physiological Research. Praha: Fyziologický ústav AV ČR, 2018, vol. 67, Suppl. 4, p. 561-576. ISSN 0862-8408.

Basic information

• Original name: Cardiac sigma receptors - An update
• Name in Czech: Srdeční sigma receptory - update
• Authors: STRAČINA, Tibor (703 Slovakia, belonging to the institution) and Marie NOVÁKOVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Physiological Research, Praha, Fyziologický ústav AV ČR, 2018, 0862-8408.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30105 Physiology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 1.701
• RIV identification code: RIV/00216224:14110/18:00105652
• Organization unit: Faculty of Medicine
• UT WoS: 000454598300002
• Keywords (in Czech): sigma receptor; srdce; chaperone; stress endoplazmatického retikula
• Keywords in English: sigma receptor; heart; chaperone; endoplasmic reticulum stress
• Tags: 14110515, rivok
• Tags: International impact, Reviewed

Abstract

More than four decades passed since sigma receptors were first mentioned. Since then, existence of at least two receptor subtypes and their tissue distributions have been proposed. Nowadays, it is clear, that sigma receptors are unique ubiquitous proteins with pluripotent function, which can interact with so many different classes of proteins. As the endoplasmic resident proteins, they work as molecular chaperones – accompany various proteins during their folding, ensure trafficking of the maturated proteins between cellular organelles and regulate their functions. In the heart, sigma receptor type 1 is more dominant. Cardiac sigma 1 receptors regulate response to endoplasmic reticulum stress, modulates calcium signaling in cardiomyocyte and can affect function of voltage-gated ion channels. They contributed in pathophysiology of cardiac hypertrophy, heart failure and many other cardiovascular disorders. Therefore, sigma receptors are potential novel targets for specific treatment of cardiovascular diseases.

Links

• MUNI/A/1157/2017, interní kód MU: Name: Kardiovaskulární systém napříč obory - od molekulární diagnostiky po klinická vyšetření (Acronym: KADIMOKLIN)

Investor: Masaryk University, Category A