Cardiac sigma receptors - An update

J 2018

Cardiac sigma receptors - An update

STRAČINA, Tibor and Marie NOVÁKOVÁ

Basic information

Original name

Cardiac sigma receptors - An update

Name in Czech

Srdeční sigma receptory - update

Authors

STRAČINA, Tibor (703 Slovakia, belonging to the institution) and Marie NOVÁKOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Physiological Research, Praha, Fyziologický ústav AV ČR, 2018, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.701

RIV identification code

RIV/00216224:14110/18:00105652

Organization unit

Faculty of Medicine

UT WoS

000454598300002

Keywords (in Czech)

sigma receptor; srdce; chaperone; stress endoplazmatického retikula

Keywords in English

sigma receptor; heart; chaperone; endoplasmic reticulum stress

Abstract

V originále

More than four decades passed since sigma receptors were first mentioned. Since then, existence of at least two receptor subtypes and their tissue distributions have been proposed. Nowadays, it is clear, that sigma receptors are unique ubiquitous proteins with pluripotent function, which can interact with so many different classes of proteins. As the endoplasmic resident proteins, they work as molecular chaperones – accompany various proteins during their folding, ensure trafficking of the maturated proteins between cellular organelles and regulate their functions. In the heart, sigma receptor type 1 is more dominant. Cardiac sigma 1 receptors regulate response to endoplasmic reticulum stress, modulates calcium signaling in cardiomyocyte and can affect function of voltage-gated ion channels. They contributed in pathophysiology of cardiac hypertrophy, heart failure and many other cardiovascular disorders. Therefore, sigma receptors are potential novel targets for specific treatment of cardiovascular diseases.

Links

MUNI/A/1157/2017, interní kód MU

Name: Kardiovaskulární systém napříč obory - od molekulární diagnostiky po klinická vyšetření (Acronym: KADIMOKLIN)

Investor: Masaryk University, Category A

Citovat

STRAČINA, Tibor and Marie NOVÁKOVÁ. Cardiac sigma receptors - An update. Physiological Research. Praha: Fyziologický ústav AV ČR, 2018, vol. 67, Suppl. 4, p. 561-576. ISSN 0862-8408.

@article{1488006,
   author = {Stračina, Tibor and Nováková, Marie},
   article_location = {Praha},
   article_number = {Suppl. 4},
   keywords = {sigma receptor; heart; chaperone; endoplasmic reticulum stress},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Cardiac sigma receptors - An update},
   url = {https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=2ahUKEwjI3PKPm_ffAhUHTBoKHVuvBJYQFjABegQICRAC&url=http%3A%2F%2Fwww.biomed.cas.cz%2Fphysiolres%2Fpdf%2F2018%2F67_S561.pdf&usg=AOvVaw1ZKYQeeUloHDzRF7-6AWyN},
   volume = {67},
   year = {2018}
}

TY  - JOUR
ID  - 1488006
AU  - Stračina, Tibor - Nováková, Marie
PY  - 2018
TI  - Cardiac sigma receptors - An update
JF  - Physiological Research
VL  - 67
IS  - Suppl. 4
SP  - 561-576
EP  - 561-576
PB  - Fyziologický ústav AV ČR
SN  - 08628408
KW  - sigma receptor
KW  - heart
KW  - chaperone
KW  - endoplasmic reticulum stress
UR  - https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=2ahUKEwjI3PKPm_ffAhUHTBoKHVuvBJYQFjABegQICRAC&url=http%3A%2F%2Fwww.biomed.cas.cz%2Fphysiolres%2Fpdf%2F2018%2F67_S561.pdf&usg=AOvVaw1ZKYQeeUloHDzRF7-6AWyN
N2  - More than four decades passed since sigma receptors were first mentioned. Since then, existence of at least two receptor subtypes and their tissue distributions have been proposed. Nowadays, it is clear, that sigma receptors are unique ubiquitous proteins with pluripotent function, which can interact with so many different classes of proteins. As the endoplasmic resident proteins, they work as molecular chaperones – accompany various proteins during their folding, ensure trafficking of the maturated proteins between cellular organelles and regulate their functions. In the heart, sigma receptor type 1 is more dominant. Cardiac sigma 1 receptors regulate response to endoplasmic reticulum stress, modulates calcium signaling in cardiomyocyte and can affect function of voltage-gated ion channels. They contributed in pathophysiology of cardiac hypertrophy, heart failure and many other cardiovascular disorders. Therefore, sigma receptors are potential novel targets for specific treatment of cardiovascular diseases.
ER  -

STRAČINA, Tibor and Marie NOVÁKOVÁ. Cardiac sigma receptors - An update. \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, 2018, vol.~67, Suppl. 4, p.~561-576. ISSN~0862-8408.

Detailed Information on Publication Record