Haloperidol affects coupling between QT and RR intervals in
guinea pig isolated heart

J 2019

Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart

VESELÝ, Petr, Tibor STRAČINA, Miroslava HLAVÁČOVÁ, Josef HALÁMEK, Jana KOLÁŘOVÁ et. al.

Basic information

Original name

Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart

Name in Czech

Haloperidol ovlivňuje spojení mezi QT a RR intervalem u izolovaného srdce morčete

Authors

VESELÝ, Petr (203 Czech Republic), Tibor STRAČINA (703 Slovakia, guarantor, belonging to the institution), Miroslava HLAVÁČOVÁ (703 Slovakia, belonging to the institution), Josef HALÁMEK (203 Czech Republic), Jana KOLÁŘOVÁ (203 Czech Republic), Veronika OLEJNÍČKOVÁ (203 Czech Republic, belonging to the institution), Veronika MRKVICOVÁ (203 Czech Republic, belonging to the institution), Hana PAULOVÁ (203 Czech Republic, belonging to the institution) and Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution)

Edition

JOURNAL OF PHARMACOLOGICAL SCIENCES, KYOTO, JAPANESE PHARMACOLOGICAL SOC, 2019, 1347-8613

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Japan

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.835

RIV identification code

RIV/00216224:14110/19:00109024

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jphs.2018.11.004

UT WoS

000454120200004

Keywords (in Czech)

léky indukované prodloužení QT; morče; haloperidol; izolované srdce; QT/RR coupling

Keywords in English

Drug-induced QT prolongation; Guinea pig; Haloperidol; Isolated heart; QT/RR coupling

Abstract

V originále

Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation. Previous studies showed that haloperidol affects not only QT duration but also heart rate (RR interval). The present work focused on relationship between QT and RR and its changes under acute and chronic haloperidol administration. The study included 14 male guinea pigs divided into control and haloperidol-treated group. After 21-days administration of haloperidol or vehiculum, electrograms in isolated hearts were recorded. QT/RR and dQT/dRR coupling were calculated. Chronic haloperidol administration significantly decreases the coupling between QT and RR. Acute haloperidol exposure significantly decreases the dQT/dRR coupling in both treated and untreated guinea pig hearts. Flatter QT/RR relationship reveals a lack of QT adaptation to increased heart rate. It should be emphasized that in such situation ECG recording will not show significant QT prolongation evaluated according to clinical rules. However, if QT interval does not adapt to increased heart rate sufficiently, the risk of ventricular arrhythmias may be increased despite practically normal QT interval length. The results are supported by findings in biochemical analyses, which proved eligibility of the used model. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Links

MUNI/A/0910/2017, interní kód MU

Name: Studium molekulární podstaty vybraných patologických stavů a onemocnění (Acronym: stumopo)

Investor: Masaryk University, Category A

MUNI/A/1157/2017, interní kód MU

Name: Kardiovaskulární systém napříč obory - od molekulární diagnostiky po klinická vyšetření (Acronym: KADIMOKLIN)

Investor: Masaryk University, Category A

Citovat

VESELÝ, Petr, Tibor STRAČINA, Miroslava HLAVÁČOVÁ, Josef HALÁMEK, Jana KOLÁŘOVÁ, Veronika OLEJNÍČKOVÁ, Veronika MRKVICOVÁ, Hana PAULOVÁ and Marie NOVÁKOVÁ. Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart. JOURNAL OF PHARMACOLOGICAL SCIENCES. KYOTO: JAPANESE PHARMACOLOGICAL SOC, 2019, vol. 139, No 1, p. 23-28. ISSN 1347-8613. Available from: https://dx.doi.org/10.1016/j.jphs.2018.11.004.

@article{1488007,
   author = {Veselý, Petr and Stračina, Tibor and Hlaváčová, Miroslava and Halámek, Josef and Kolářová, Jana and Olejníčková, Veronika and Mrkvicová, Veronika and Paulová, Hana and Nováková, Marie},
   article_location = {KYOTO},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.jphs.2018.11.004},
   keywords = {Drug-induced QT prolongation; Guinea pig; Haloperidol; Isolated heart; QT/RR coupling},
   language = {eng},
   issn = {1347-8613},
   journal = {JOURNAL OF PHARMACOLOGICAL SCIENCES},
   title = {Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart},
   url = {https://doi.org/10.1016/j.jphs.2018.11.004},
   volume = {139},
   year = {2019}
}

TY  - JOUR
ID  - 1488007
AU  - Veselý, Petr - Stračina, Tibor - Hlaváčová, Miroslava - Halámek, Josef - Kolářová, Jana - Olejníčková, Veronika - Mrkvicová, Veronika - Paulová, Hana - Nováková, Marie
PY  - 2019
TI  - Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart
JF  - JOURNAL OF PHARMACOLOGICAL SCIENCES
VL  - 139
IS  - 1
SP  - 23-28
EP  - 23-28
PB  - JAPANESE PHARMACOLOGICAL SOC
SN  - 13478613
KW  - Drug-induced QT prolongation
KW  - Guinea pig
KW  - Haloperidol
KW  - Isolated heart
KW  - QT/RR coupling
UR  - https://doi.org/10.1016/j.jphs.2018.11.004
L2  - https://doi.org/10.1016/j.jphs.2018.11.004
N2  - Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation. Previous studies showed that haloperidol affects not only QT duration but also heart rate (RR interval). The present work focused on relationship between QT and RR and its changes under acute and chronic haloperidol administration. The study included 14 male guinea pigs divided into control and haloperidol-treated group. After 21-days administration of haloperidol or vehiculum, electrograms in isolated hearts were recorded. QT/RR and dQT/dRR coupling were calculated. Chronic haloperidol administration significantly decreases the coupling between QT and RR. Acute haloperidol exposure significantly decreases the dQT/dRR coupling in both treated and untreated guinea pig hearts. Flatter QT/RR relationship reveals a lack of QT adaptation to increased heart rate. It should be emphasized that in such situation ECG recording will not show significant QT prolongation evaluated according to clinical rules. However, if QT interval does not adapt to increased heart rate sufficiently, the risk of ventricular arrhythmias may be increased despite practically normal QT interval length. The results are supported by findings in biochemical analyses, which proved eligibility of the used model. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
ER  -

VESELÝ, Petr, Tibor STRAČINA, Miroslava HLAVÁČOVÁ, Josef HALÁMEK, Jana KOLÁŘOVÁ, Veronika OLEJNÍČKOVÁ, Veronika MRKVICOVÁ, Hana PAULOVÁ and Marie NOVÁKOVÁ. Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart. \textit{JOURNAL OF PHARMACOLOGICAL SCIENCES}. KYOTO: JAPANESE PHARMACOLOGICAL SOC, 2019, vol.~139, No~1, p.~23-28. ISSN~1347-8613. Available from: https://dx.doi.org/10.1016/j.jphs.2018.11.004.

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