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@article{1488064,
author = {Moosová, Zdena and Hrouzek, Pavel and Kapuscik, Aleksandra and Bláha, Luděk and Adamovský, Ondřej},
article_location = {OXFORD},
article_number = {July},
doi = {http://dx.doi.org/10.1016/j.toxicon.2018.04.031},
keywords = {Cyanobacteria; Cyanotoxins; Innate immunity; Macrophages},
language = {eng},
issn = {0041-0101},
journal = {Toxicon},
title = {Immunomodulatory effects of selected cyanobacterial peptides in vitro},
url = {https://www.sciencedirect.com/science/article/pii/S0041010118301740},
volume = {149},
year = {2018}
}
TY - JOUR
ID - 1488064
AU - Moosová, Zdena - Hrouzek, Pavel - Kapuscik, Aleksandra - Bláha, Luděk - Adamovský, Ondřej
PY - 2018
TI - Immunomodulatory effects of selected cyanobacterial peptides in vitro
JF - Toxicon
VL - 149
IS - July
SP - 20-25
EP - 20-25
PB - PERGAMON-ELSEVIER SCIENCE LTD
SN - 00410101
KW - Cyanobacteria
KW - Cyanotoxins
KW - Innate immunity
KW - Macrophages
UR - https://www.sciencedirect.com/science/article/pii/S0041010118301740
L2 - https://www.sciencedirect.com/science/article/pii/S0041010118301740
N2 - Cyanobacteria produce many biologically active metabolites synthesized via nonribosomal synthetic pathways such as cyclic microcystins (MCs) and linear aeruginosins (Aers). The present study aimed to investigate the effects of different MC variants and the newly isolated aerugenosin Aer-865 on macrophages, which represent one of the key effector cells within the innate immune responses. Specifically, our study included RAW 264.7 macrophage activation associated with production of cytotoxic and cytostatic nitric oxide (NO) as well as pro-inflammatory mediators like tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6). From the compounds investigated, commonly occurring MC variants (-RR,-YR) and Aer-865 had no significant effects within the non-cytotoxic concentrations tested, i.e. 0.001-1 mu M for MCs and 0.1-50 mu M for Aer-865. In contrast to known immunoactive MC-LR, the negligible immunomodulatory potential of tested MC congeners could be related to their differences in structure. The knowledge of MC structure-specific activities contributes to the understanding of complex toxicity of different MC variants and most importantly their mixtures. This study is one of the first study that evaluate the effect of larger set of cyanobacterial peptides on macrophages and compare their immunomodulatory potential.
ER -
MOOSOVÁ, Zdena, Pavel HROUZEK, Aleksandra KAPUSCIK, Luděk BLÁHA and Ondřej ADAMOVSKÝ. Immunomodulatory effects of selected cyanobacterial peptides in vitro. \textit{Toxicon}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2018, vol.~149, July, p.~20-25. ISSN~0041-0101. Available from: https://dx.doi.org/10.1016/j.toxicon.2018.04.031.
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