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@article{1488073,
author = {Toušová, Zuzana and Froment, Jean and Oswald, Peter and Slobodník, Jaroslav and Hilscherová, Klára and Thomas, Kevin V. and Tollefsen, Knut Erik and Reid, Malcolm and Langford, Katherine and Bláha, Luděk},
article_location = {Amsterdam},
article_number = {September},
doi = {http://dx.doi.org/10.1016/j.jhazmat.2018.05.031},
keywords = {Contaminants of emerging concern; Effect directed analysis; Fractionation; Non-target screening; Toxicity drivers},
language = {eng},
issn = {0304-3894},
journal = {Journal of Hazardous Materials},
title = {Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques},
url = {https://www.sciencedirect.com/science/article/pii/S0304389418303807?via%3Dihub},
volume = {358},
year = {2018}
}
TY - JOUR
ID - 1488073
AU - Toušová, Zuzana - Froment, Jean - Oswald, Peter - Slobodník, Jaroslav - Hilscherová, Klára - Thomas, Kevin V. - Tollefsen, Knut Erik - Reid, Malcolm - Langford, Katherine - Bláha, Luděk
PY - 2018
TI - Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques
JF - Journal of Hazardous Materials
VL - 358
IS - September
SP - 494-502
EP - 494-502
PB - Elsevier Science BV.
SN - 03043894
KW - Contaminants of emerging concern
KW - Effect directed analysis
KW - Fractionation
KW - Non-target screening
KW - Toxicity drivers
UR - https://www.sciencedirect.com/science/article/pii/S0304389418303807?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S0304389418303807?via%3Dihub
N2 - Growth inhibition of freshwater microalga Pseudokirchneriella subcapitata caused by a waste water treatment plant (WWTP) effluent extract was investigated using an effect directed analysis (EDA) approach. The objective was to identify compounds responsible for the toxicity by combining state-of-the-art sampling, bioanalytical, fractionation and non-target screening techniques. Three fractionation steps of the whole extract were performed and bioactive fractions were analysed with GC (xGC)-MS and LC-HRMS. In total, 383 compounds were tentatively identified, and their toxicity was characterized using US EPA Ecotox database, open scientific literature or modelled by ECOSAR. Among the top-ranking drivers of toxicity were pesticides and their transformation products, pharmaceuticals (barbiturate derivatives and macrolide antibiotics e.g. azithromycin), industrial compounds or caffeine and its metabolites. Several of the top-ranking pesticides are no longer registered for use in plant protection products or biocides in the Czech Republic (e.g. prometryn, atrazine, acetochlor, resmethrin) and some are approved only for use in biocides (e.g. terbutryn, carbendazim, phenothrin), which indicates that their non-agricultural input into aquatic environment via WWT'Ps should be carefully considered. The study demonstrated a functional strategy of combining biotesting, fractionation and non-target screening techniques in the EDA study focused on the identification of algal growth inhibitors in WWTP effluent.
ER -
TOUŠOVÁ, Zuzana, Jean FROMENT, Peter OSWALD, Jaroslav SLOBODNÍK, Klára HILSCHEROVÁ, Kevin V. THOMAS, Knut Erik TOLLEFSEN, Malcolm REID, Katherine LANGFORD and Luděk BLÁHA. Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques. \textit{Journal of Hazardous Materials}. Amsterdam: Elsevier Science BV., 2018, vol.~358, September, p.~494-502. ISSN~0304-3894. Available from: https://dx.doi.org/10.1016/j.jhazmat.2018.05.031.
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