ŠTACKO, Peter, Lucie MUCHOVA, Libor VITEK and Petr KLÁN. Visible to NIR Light Photoactivation of Hydrogen Sulfide for Biological Targeting. Organic Letters. WASHINGTON: American Chemical Society, 2018, vol. 20, No 16, p. 4907-4911. ISSN 1523-7060. Available from: https://dx.doi.org/10.1021/acs.orglett.8b02043.
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Basic information
Original name Visible to NIR Light Photoactivation of Hydrogen Sulfide for Biological Targeting
Authors ŠTACKO, Peter (703 Slovakia, belonging to the institution), Lucie MUCHOVA (203 Czech Republic), Libor VITEK (203 Czech Republic) and Petr KLÁN (203 Czech Republic, guarantor, belonging to the institution).
Edition Organic Letters, WASHINGTON, American Chemical Society, 2018, 1523-7060.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10401 Organic chemistry
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 6.555
RIV identification code RIV/00216224:14310/18:00101605
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1021/acs.orglett.8b02043
UT WoS 000442454900042
Keywords in English PHOTOREMOVABLE PROTECTING GROUPS; GASEOUS SIGNALING MOLECULE; PHOTODYNAMIC THERAPY; FLUORESCENT-PROBES; METHYLENE-BLUE; BODIPY DYES; GREEN-LIGHT; RELEASE; H2S; DERIVATIVES
Tags International impact, Reviewed
Changed by Changed by: Mgr. Michaela Hylsová, Ph.D., učo 211937. Changed: 18/1/2019 15:58.
Abstract
The synthesis and photochemical properties of H2S-releasing BODIPY thiocarbamate photocage scaffolds activatable by visible-to-NIR (up to 700 nm) light to release carbonyl sulfide (COS), which is transformed to H2S using either isolated or natural carbonic anhydrase, is reported. The excellent uncaging cross section and high H2S release yields in in vitro experiments, including live-cell imaging, suggest that these photocages can serve as a platform for the bio-orthogonal phototriggered release within the tissue-transparent window.
Links
CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MUName: RECETOX RI - OP VVV (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR, Priority axis 1: Strengthening capacities for high-quality research
GA18-12477S, research and development projectName: Fotoaktivace CO a H2S jako plynných signálních molekul pro biologické a medicinální aplikace
Investor: Czech Science Foundation
LM2015051, research and development projectName: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR
6SA17811, interní kód MUName: Visible light-activated photocaged molecules for biological applications (Acronym: VLAMBA)
Investor: South-Moravian Region, Incoming grants
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