In Vitro Inhalation Bioaccessibility of Phthalate Esters and
Alternative Plasticizers Present in Indoor Dust Using
Artificial Lung Fluids

J 2018

In Vitro Inhalation Bioaccessibility of Phthalate Esters and Alternative Plasticizers Present in Indoor Dust Using Artificial Lung Fluids

KADEMOGLOU, Aikaterini, Georgios GIOVANOULIS, Anna PALM-COUSINS, Juan Antonio PADILLA-SANCHEZ, Jorgen MAGNER et. al.

Basic information

Original name

In Vitro Inhalation Bioaccessibility of Phthalate Esters and Alternative Plasticizers Present in Indoor Dust Using Artificial Lung Fluids

Authors

KADEMOGLOU, Aikaterini (300 Greece, guarantor, belonging to the institution), Georgios GIOVANOULIS (752 Sweden), Anna PALM-COUSINS (752 Sweden), Juan Antonio PADILLA-SANCHEZ (578 Norway), Jorgen MAGNER (752 Sweden), Cynthia A. DE WIT (752 Sweden) and Christopher D. COLLIN (826 United Kingdom of Great Britain and Northern Ireland)

Edition

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, WASHINGTON, AMER CHEMICAL SOC, 2018, 2328-8930

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10511 Environmental sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.934

RIV identification code

RIV/00216224:14310/18:00105752

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1021/acs.estlett.8b00113

UT WoS

000435417000006

Keywords in English

SEMIVOLATILE ORGANIC-COMPOUNDS; DAY-CARE-CENTERS; HUMAN EXPOSURE; FLAME RETARDANTS; RISK-ASSESSMENT; SETTLED DUST; SIZE FRACTION; HUMAN HEALTH; ACID ESTERS; HOUSE DUST

Abstract

V originále

Phthalate esters (PEs) are used as plasticizers in consumer products. Their low migration stability has resulted in the classification of PEs as major indoor contaminants. Because of PE's ubiquity and adverse health effects on humans and especially children, non-phthalate alternative plasticizers have been introduced into the market. This is the first study of in vitro inhalation bioaccessibility of PEs (e.g., DMP, DEP, and DEHP) and alternative plasticizers (e.g., DEHT and DINCH) via indoor dust to assess inhalation as an alternative route of exposure. Two artificial lung fluids were used, mimicking two distinctively different pulmonary environments: (1) artificial lysosomal fluid (ALF, pH 4.5) representing the intracellular acidic lung fluid inhaled particle contact after phagocytosis by alveolar macrophages and (2) Gamble's solution (pH 7.4), the extracellular healthy fluid for deep lung deposition of dust. DMP and DEP were highly bioaccessible (>75%), whereas highly hydrophobic compounds such as DEHP, DINCH, and DEHT were <5% bioaccessible via both artificial lung fluids. Our findings show that the inhalation bioaccessibility of PEs is primarily governed by their hydrophobicity and water solubility. Further research is necessary to develop unified and biologically relevant inhalation bioaccessibility tests, employed as part of human risk assessment of volatile and semivolatile organic pollutants.

Citovat

KADEMOGLOU, Aikaterini, Georgios GIOVANOULIS, Anna PALM-COUSINS, Juan Antonio PADILLA-SANCHEZ, Jorgen MAGNER, Cynthia A. DE WIT and Christopher D. COLLIN. In Vitro Inhalation Bioaccessibility of Phthalate Esters and Alternative Plasticizers Present in Indoor Dust Using Artificial Lung Fluids. ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS. WASHINGTON: AMER CHEMICAL SOC, 2018, vol. 5, No 6, p. 329-334. ISSN 2328-8930. Available from: https://dx.doi.org/10.1021/acs.estlett.8b00113.

@article{1488703,
   author = {Kademoglou, Aikaterini and Giovanoulis, Georgios and PalmandCousins, Anna and PadillaandSanchez, Juan Antonio and Magner, Jorgen and de Wit, Cynthia A. and Collin, Christopher D.},
   article_location = {WASHINGTON},
   article_number = {6},
   doi = {http://dx.doi.org/10.1021/acs.estlett.8b00113},
   keywords = {SEMIVOLATILE ORGANIC-COMPOUNDS; DAY-CARE-CENTERS; HUMAN EXPOSURE; FLAME RETARDANTS; RISK-ASSESSMENT; SETTLED DUST; SIZE FRACTION; HUMAN HEALTH; ACID ESTERS; HOUSE DUST},
   language = {eng},
   issn = {2328-8930},
   journal = {ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS},
   title = {In Vitro Inhalation Bioaccessibility of Phthalate Esters and Alternative Plasticizers Present in Indoor Dust Using Artificial Lung Fluids},
   url = {https://pubs.acs.org/doi/10.1021/acs.estlett.8b00113},
   volume = {5},
   year = {2018}
}

TY  - JOUR
ID  - 1488703
AU  - Kademoglou, Aikaterini - Giovanoulis, Georgios - Palm-Cousins, Anna - Padilla-Sanchez, Juan Antonio - Magner, Jorgen - de Wit, Cynthia A. - Collin, Christopher D.
PY  - 2018
TI  - In Vitro Inhalation Bioaccessibility of Phthalate Esters and Alternative Plasticizers Present in Indoor Dust Using Artificial Lung Fluids
JF  - ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
VL  - 5
IS  - 6
SP  - 329-334
EP  - 329-334
PB  - AMER CHEMICAL SOC
SN  - 23288930
KW  - SEMIVOLATILE ORGANIC-COMPOUNDS
KW  - DAY-CARE-CENTERS
KW  - HUMAN EXPOSURE
KW  - FLAME RETARDANTS
KW  - RISK-ASSESSMENT
KW  - SETTLED DUST
KW  - SIZE FRACTION
KW  - HUMAN HEALTH
KW  - ACID ESTERS
KW  - HOUSE DUST
UR  - https://pubs.acs.org/doi/10.1021/acs.estlett.8b00113
L2  - https://pubs.acs.org/doi/10.1021/acs.estlett.8b00113
N2  - Phthalate esters (PEs) are used as plasticizers in consumer products. Their low migration stability has resulted in the classification of PEs as major indoor contaminants. Because of PE's ubiquity and adverse health effects on humans and especially children, non-phthalate alternative plasticizers have been introduced into the market. This is the first study of in vitro inhalation bioaccessibility of PEs (e.g., DMP, DEP, and DEHP) and alternative plasticizers (e.g., DEHT and DINCH) via indoor dust to assess inhalation as an alternative route of exposure. Two artificial lung fluids were used, mimicking two distinctively different pulmonary environments: (1) artificial lysosomal fluid (ALF, pH 4.5) representing the intracellular acidic lung fluid inhaled particle contact after phagocytosis by alveolar macrophages and (2) Gamble's solution (pH 7.4), the extracellular healthy fluid for deep lung deposition of dust. DMP and DEP were highly bioaccessible (>75%), whereas highly hydrophobic compounds such as DEHP, DINCH, and DEHT were <5% bioaccessible via both artificial lung fluids. Our findings show that the inhalation bioaccessibility of PEs is primarily governed by their hydrophobicity and water solubility. Further research is necessary to develop unified and biologically relevant inhalation bioaccessibility tests, employed as part of human risk assessment of volatile and semivolatile organic pollutants.
ER  -

KADEMOGLOU, Aikaterini, Georgios GIOVANOULIS, Anna PALM-COUSINS, Juan Antonio PADILLA-SANCHEZ, Jorgen MAGNER, Cynthia A. DE WIT and Christopher D. COLLIN. In Vitro Inhalation Bioaccessibility of Phthalate Esters and Alternative Plasticizers Present in Indoor Dust Using Artificial Lung Fluids. \textit{ENVIRONMENTAL SCIENCE \&{}amp; TECHNOLOGY LETTERS}. WASHINGTON: AMER CHEMICAL SOC, 2018, vol.~5, No~6, p.~329-334. ISSN~2328-8930. Available from: https://dx.doi.org/10.1021/acs.estlett.8b00113.

Detailed Information on Publication Record