Detailed Information on Publication Record
2018
Theory of Mind Skills Are Related to Resting-State Frontolimbic Connectivity in Schizophrenia
HOLŠTAJN ZEMÁNKOVÁ, Petra, Jan LOŠÁK, Kristína CZEKÓOVÁ, Ovidiu LUNGU, Martin JÁNI et. al.Basic information
Original name
Theory of Mind Skills Are Related to Resting-State Frontolimbic Connectivity in Schizophrenia
Authors
HOLŠTAJN ZEMÁNKOVÁ, Petra (203 Czech Republic, guarantor, belonging to the institution), Jan LOŠÁK (203 Czech Republic, belonging to the institution), Kristína CZEKÓOVÁ (703 Slovakia, belonging to the institution), Ovidiu LUNGU (124 Canada), Martin JÁNI (703 Slovakia, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution) and Martin BAREŠ (203 Czech Republic, belonging to the institution)
Edition
BRAIN CONNECTIVITY, NEW ROCHELLE, MARY ANN LIEBERT, INC, 2018, 2158-0014
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/18:00105775
Organization unit
Faculty of Medicine
UT WoS
000452155400005
Keywords in English
fMRI; resting-state functional connectivity; schizophrenia; seed voxel analysis; theory of mind
Tags
International impact, Reviewed
Změněno: 18/3/2019 14:46, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
Patients with schizophrenia (SCH) often demonstrate impairment in social-cognitive functions as well as disturbances in large-scale network connectivity. The ventromedial prefrontal cortex (vmPFC) is a core region of the default mode network, with projections to limbic structures. It plays an important role in social and emotional decision-making. We investigated whether resting-state functional connectivity (FC) relates to the cognitive and affective domains of theory of mind (ToM). Twenty-three SCH patients and 19 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scanning. vmPFC seed connectivity was correlated with behavioral measures assessing ToM domains. SCH performed less well than HCs in both ToM task domains. An analysis of the resting-state FC revealed that SCH had reduced connectivity from the vmPFC to the subcallosal cortex, right amygdala, and right hippocampus as a function of behavioral scores in both ToM domains. Within-group analyses indicated that in HCs, the performance in ToM was positively associated with frontoamygdalar resting-state connectivity, whereas in SCH, the performance in ToM was negatively associated with the frontosubcallosal connectivity. Differences in the pattern of the resting-state frontolimbic connectivity and its associations with performance in ToM tasks between the two study groups might represent a different setup for processing social information in patients with SCH.