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@article{1489412,
author = {Kopková, Alena and Šána, Jiří and Fadrus, Pavel and Slabý, Ondřej},
article_location = {BERLIN},
article_number = {6},
doi = {http://dx.doi.org/10.1515/cclm-2017-0958},
keywords = {biomarker; brain cancer; cerebrospinal fluid (CSF); diagnosis; microRNA; prognosis},
language = {eng},
issn = {1434-6621},
journal = {Clinical Chemistry and Laboratory medicine},
title = {Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors},
volume = {56},
year = {2018}
}
TY - JOUR
ID - 1489412
AU - Kopková, Alena - Šána, Jiří - Fadrus, Pavel - Slabý, Ondřej
PY - 2018
TI - Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors
JF - Clinical Chemistry and Laboratory medicine
VL - 56
IS - 6
SP - 869-879
EP - 869-879
PB - WALTER DE GRUYTER & CO
SN - 14346621
KW - biomarker
KW - brain cancer
KW - cerebrospinal fluid (CSF)
KW - diagnosis
KW - microRNA
KW - prognosis
N2 - Cerebrospinal fluid (CSF) is a body fluid that has many important functions and is in direct contact with the extracellular environment of the central nervous system (CNS). CSF serves as both the communication channel allowing the distribution of various substances among the CNS cells and the storage facility for the waste products these cells release. For these reasons, CSF is a potential source of diagnostic biomarkers of many CNS diseases, including brain tumors. Recent studies have revealed that CSF also contains circulating microRNAs (miRNAs), short non-coding RNAs that have been described as biomarkers in many cancers. However, CSF miRNAs are difficult to detect, which is why researchers face major challenges, including technological difficulties in its detection and its lack of standardization. Therefore, this review aims (i) to highlight the potential of CSF miRNAs as diagnostic, prognostic and predictive biomarkers in brain tumors, and (ii) to summarize technological approaches for detection of CSF miRNAs.
ER -
KOPKOVÁ, Alena, Jiří ŠÁNA, Pavel FADRUS a Ondřej SLABÝ. Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors. \textit{Clinical Chemistry and Laboratory medicine}. BERLIN: WALTER DE GRUYTER \&{}amp; CO, roč.~56, č.~6, s.~869-879. ISSN~1434-6621. doi:10.1515/cclm-2017-0958. 2018.
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