Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain
tumors

J 2018

Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors

KOPKOVÁ, Alena, Jiří ŠÁNA, Pavel FADRUS and Ondřej SLABÝ

Basic information

Original name

Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors

Authors

KOPKOVÁ, Alena (203 Czech Republic, belonging to the institution), Jiří ŠÁNA (203 Czech Republic, belonging to the institution), Pavel FADRUS (203 Czech Republic, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Clinical Chemistry and Laboratory medicine, BERLIN, WALTER DE GRUYTER & CO, 2018, 1434-6621

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

20602 Medical laboratory technology ;

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.638

RIV identification code

RIV/00216224:14740/18:00105814

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1515/cclm-2017-0958

UT WoS

000431126000012

Keywords in English

biomarker; brain cancer; cerebrospinal fluid (CSF); diagnosis; microRNA; prognosis

Abstract

V originále

Cerebrospinal fluid (CSF) is a body fluid that has many important functions and is in direct contact with the extracellular environment of the central nervous system (CNS). CSF serves as both the communication channel allowing the distribution of various substances among the CNS cells and the storage facility for the waste products these cells release. For these reasons, CSF is a potential source of diagnostic biomarkers of many CNS diseases, including brain tumors. Recent studies have revealed that CSF also contains circulating microRNAs (miRNAs), short non-coding RNAs that have been described as biomarkers in many cancers. However, CSF miRNAs are difficult to detect, which is why researchers face major challenges, including technological difficulties in its detection and its lack of standardization. Therefore, this review aims (i) to highlight the potential of CSF miRNAs as diagnostic, prognostic and predictive biomarkers in brain tumors, and (ii) to summarize technological approaches for detection of CSF miRNAs.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

NV15-33158A, research and development project

Name: Nová úroveň molekulární taxonomie glioblastomu založená na expresních profilech dlouhých nekódujících RNA: implikace pro diagnostiku a terapii

NV15-34553A, research and development project

Name: Využití mikroRNA v mozkomíšním moku pro diagnostiku mozkových nádorů

Citovat

KOPKOVÁ, Alena, Jiří ŠÁNA, Pavel FADRUS and Ondřej SLABÝ. Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors. Clinical Chemistry and Laboratory medicine. BERLIN: WALTER DE GRUYTER & CO, 2018, vol. 56, No 6, p. 869-879. ISSN 1434-6621. Available from: https://dx.doi.org/10.1515/cclm-2017-0958.

@article{1489412,
   author = {Kopková, Alena and Šána, Jiří and Fadrus, Pavel and Slabý, Ondřej},
   article_location = {BERLIN},
   article_number = {6},
   doi = {http://dx.doi.org/10.1515/cclm-2017-0958},
   keywords = {biomarker; brain cancer; cerebrospinal fluid (CSF); diagnosis; microRNA; prognosis},
   language = {eng},
   issn = {1434-6621},
   journal = {Clinical Chemistry and Laboratory medicine},
   title = {Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors},
   volume = {56},
   year = {2018}
}

TY  - JOUR
ID  - 1489412
AU  - Kopková, Alena - Šána, Jiří - Fadrus, Pavel - Slabý, Ondřej
PY  - 2018
TI  - Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors
JF  - Clinical Chemistry and Laboratory medicine
VL  - 56
IS  - 6
SP  - 869-879
EP  - 869-879
PB  - WALTER DE GRUYTER & CO
SN  - 14346621
KW  - biomarker
KW  - brain cancer
KW  - cerebrospinal fluid (CSF)
KW  - diagnosis
KW  - microRNA
KW  - prognosis
N2  - Cerebrospinal fluid (CSF) is a body fluid that has many important functions and is in direct contact with the extracellular environment of the central nervous system (CNS). CSF serves as both the communication channel allowing the distribution of various substances among the CNS cells and the storage facility for the waste products these cells release. For these reasons, CSF is a potential source of diagnostic biomarkers of many CNS diseases, including brain tumors. Recent studies have revealed that CSF also contains circulating microRNAs (miRNAs), short non-coding RNAs that have been described as biomarkers in many cancers. However, CSF miRNAs are difficult to detect, which is why researchers face major challenges, including technological difficulties in its detection and its lack of standardization. Therefore, this review aims (i) to highlight the potential of CSF miRNAs as diagnostic, prognostic and predictive biomarkers in brain tumors, and (ii) to summarize technological approaches for detection of CSF miRNAs.
ER  -

KOPKOVÁ, Alena, Jiří ŠÁNA, Pavel FADRUS and Ondřej SLABÝ. Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors. \textit{Clinical Chemistry and Laboratory medicine}. BERLIN: WALTER DE GRUYTER \&{}amp; CO, 2018, vol.~56, No~6, p.~869-879. ISSN~1434-6621. Available from: https://dx.doi.org/10.1515/cclm-2017-0958.

Detailed Information on Publication Record