Estimated dietary iodine intake as a predictor of placental
size: evidence from the ELSPAC study

J 2018

Estimated dietary iodine intake as a predictor of placental size: evidence from the ELSPAC study

DOBROVOLNÁ, Julie, Markéta GRULICHOVÁ, Ondřej MIKEŠ, Filip ZLÁMAL, Tomáš PRUŠA et. al.

Basic information

Original name

Estimated dietary iodine intake as a predictor of placental size: evidence from the ELSPAC study

Authors

DOBROVOLNÁ, Julie (203 Czech Republic, guarantor, belonging to the institution), Markéta GRULICHOVÁ (203 Czech Republic, belonging to the institution), Ondřej MIKEŠ (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Tomáš PRUŠA (203 Czech Republic, belonging to the institution), Aneta POHOŘALÁ (203 Czech Republic, belonging to the institution), Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution) and Hynek PIKHART (203 Czech Republic, belonging to the institution)

Edition

NUTRITION & METABOLISM, LONDON, BIOMED CENTRAL LTD, 2018, 1743-7075

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30308 Nutrition, Dietetics

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.599

RIV identification code

RIV/00216224:14310/18:00105834

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1186/s12986-018-0240-8

UT WoS

000422983500001

Keywords in English

Iodine intake; Placental weight; Birth weight/placental weight; Birth outcome; ELSPAC

Abstract

V originále

Background: The relationship between low iodine status and pregnancy-associated comorbidities has been known for decades. The relationship between iodine intake and placental pathologies is, however, far less clear. This study was designed to examine the relationship between dietary iodine intake and placental size while also focusing on typical adverse pregnancy outcomes. Method: The dietary iodine intake of 4711 pregnant women enrolled in the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) in 1990-1991 was established using a 145-item food frequency questionnaire. Multivariate linear regression models were used to estimate the relationship between dietary iodine intake during pregnancy and placental weight. Additional models were constructed to investigate the relationship between estimated dietary iodine intake and adverse birth outcomes. Results: The estimated average iodine intake in the ELSPAC cohort was 106.6 mu g/day. In the fully adjusted model, estimated dietary iodine intake was found to be significantly negatively associated with placental weight (beta = -0.025, 95% CI: -0.044; -0.006, p = 0.011). Moreover, estimated dietary iodine intake was found to be significantly positively associated with the birth weight /placental weight ratio in the fully adjusted model (beta = -0.024, 95% CI: 0.004; 0.043, p = 0.016). Conclusions: This study provides evidence of a relationship between estimated dietary iodine intake and placental weight and the birth weight /placental weight ratio. Additional research is warranted to provide more insight into the role of iodine in early as well as late placentation.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

DOBROVOLNÁ, Julie, Markéta GRULICHOVÁ, Ondřej MIKEŠ, Filip ZLÁMAL, Tomáš PRUŠA, Aneta POHOŘALÁ, Lenka ANDRÝSKOVÁ and Hynek PIKHART. Estimated dietary iodine intake as a predictor of placental size: evidence from the ELSPAC study. NUTRITION & METABOLISM. LONDON: BIOMED CENTRAL LTD, 2018, vol. 15, JAN 17 2018, p. 1-14. ISSN 1743-7075. Available from: https://dx.doi.org/10.1186/s12986-018-0240-8.

@article{1489818,
   author = {Dobrovolná, Julie and Grulichová, Markéta and Mikeš, Ondřej and Zlámal, Filip and Pruša, Tomáš and Pohořalá, Aneta and Andrýsková, Lenka and Pikhart, Hynek},
   article_location = {LONDON},
   article_number = {JAN 17 2018},
   doi = {http://dx.doi.org/10.1186/s12986-018-0240-8},
   keywords = {Iodine intake; Placental weight; Birth weight/placental weight; Birth outcome; ELSPAC},
   language = {eng},
   issn = {1743-7075},
   journal = {NUTRITION & METABOLISM},
   title = {Estimated dietary iodine intake as a predictor of placental size: evidence from the ELSPAC study},
   url = {http://dx.doi.org/10.1186/s12986-018-0240-8},
   volume = {15},
   year = {2018}
}

TY  - JOUR
ID  - 1489818
AU  - Dobrovolná, Julie - Grulichová, Markéta - Mikeš, Ondřej - Zlámal, Filip - Pruša, Tomáš - Pohořalá, Aneta - Andrýsková, Lenka - Pikhart, Hynek
PY  - 2018
TI  - Estimated dietary iodine intake as a predictor of placental size: evidence from the ELSPAC study
JF  - NUTRITION & METABOLISM
VL  - 15
IS  - JAN 17 2018
SP  - 1-14
EP  - 1-14
PB  - BIOMED CENTRAL LTD
SN  - 17437075
KW  - Iodine intake
KW  - Placental weight
KW  - Birth weight/placental weight
KW  - Birth outcome
KW  - ELSPAC
UR  - http://dx.doi.org/10.1186/s12986-018-0240-8
N2  - Background: The relationship between low iodine status and pregnancy-associated comorbidities has been known for decades. The relationship between iodine intake and placental pathologies is, however, far less clear. This study was designed to examine the relationship between dietary iodine intake and placental size while also focusing on typical adverse pregnancy outcomes. Method: The dietary iodine intake of 4711 pregnant women enrolled in the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) in 1990-1991 was established using a 145-item food frequency questionnaire. Multivariate linear regression models were used to estimate the relationship between dietary iodine intake during pregnancy and placental weight. Additional models were constructed to investigate the relationship between estimated dietary iodine intake and adverse birth outcomes. Results: The estimated average iodine intake in the ELSPAC cohort was 106.6 mu g/day. In the fully adjusted model, estimated dietary iodine intake was found to be significantly negatively associated with placental weight (beta = -0.025, 95% CI: -0.044; -0.006, p = 0.011). Moreover, estimated dietary iodine intake was found to be significantly positively associated with the birth weight /placental weight ratio in the fully adjusted model (beta = -0.024, 95% CI: 0.004; 0.043, p = 0.016). Conclusions: This study provides evidence of a relationship between estimated dietary iodine intake and placental weight and the birth weight /placental weight ratio. Additional research is warranted to provide more insight into the role of iodine in early as well as late placentation.
ER  -

DOBROVOLNÁ, Julie, Markéta GRULICHOVÁ, Ondřej MIKEŠ, Filip ZLÁMAL, Tomáš PRUŠA, Aneta POHOŘALÁ, Lenka ANDRÝSKOVÁ and Hynek PIKHART. Estimated dietary iodine intake as a predictor of placental size: evidence from the ELSPAC study. \textit{NUTRITION \&{} METABOLISM}. LONDON: BIOMED CENTRAL LTD, 2018, vol.~15, JAN 17 2018, p.~1-14. ISSN~1743-7075. Available from: https://dx.doi.org/10.1186/s12986-018-0240-8.

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