| ŠÁNA, Jiří, Petr BUŠEK, Pavel FADRUS, Andrej BEŠŠE, Lenka RADOVÁ, Marek VEČEŘA, Stefan REGULI, Lucie SROMOVA STOLLINOVA, Marek HILSER, Radim LIPINA, Radek LAKOMÝ, Leoš KŘEN, Martin SMRČKA, Aleksi ŠEDO and Ondřej SLABÝ. Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2018, vol. 8, FEB, p. 2836-2846. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-20929-6. |
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@article{1489878,
author = {Šána, Jiří and Bušek, Petr and Fadrus, Pavel and Bešše, Andrej and Radová, Lenka and Večeřa, Marek and Reguli, Stefan and Sromova Stollinova, Lucie and Hilser, Marek and Lipina, Radim and Lakomý, Radek and Křen, Leoš and Smrčka, Martin and Šedo, Aleksi and Slabý, Ondřej},
article_location = {LONDON},
article_number = {FEB},
doi = {http://dx.doi.org/10.1038/s41598-018-20929-6},
keywords = {Glioblastoma stem-like cells},
language = {eng},
issn = {2045-2322},
journal = {Scientific reports},
title = {Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival},
volume = {8},
year = {2018}
}
TY - JOUR
ID - 1489878
AU - Šána, Jiří - Bušek, Petr - Fadrus, Pavel - Bešše, Andrej - Radová, Lenka - Večeřa, Marek - Reguli, Stefan - Sromova Stollinova, Lucie - Hilser, Marek - Lipina, Radim - Lakomý, Radek - Křen, Leoš - Smrčka, Martin - Šedo, Aleksi - Slabý, Ondřej
PY - 2018
TI - Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival
JF - Scientific reports
VL - 8
IS - FEB
SP - 2836
EP - 2836
PB - NATURE PUBLISHING GROUP
SN - 20452322
KW - Glioblastoma stem-like cells
N2 - Glioblastoma stem-like cells (GSCs) are critical for the aggressiveness and progression of glioblastoma (GBM) and contribute to its resistance to adjuvant treatment. MicroRNAs (miRNAs) are small, non-coding RNAs controlling gene expression at the post-transcriptional level, which are known to be important regulators of the stem-like features. Moreover, miRNAs have been previously proved to be promising diagnostic biomarkers in several cancers including GBM. Using global expression analysis of miRNAs in 10 paired in-vitro as well as in-vivo characterized primary GSC and non-stem glioblastoma cultures, we identified a miRNA signature associated with the stem-like phenotype in GBM. 51 most deregulated miRNAs classified the cell cultures into GSC and non-stem cell clusters and identified a subgroup of GSC cultures with more pronounced stem-cell characteristics. The importance of the identified miRNA signature was further supported by demonstrating that a Risk Score based on the expression of seven miRNAs overexpressed in GSC predicted overall survival in GBM patients in the TCGA dataset independently of the IDH1 status. In summary, we identified miRNAs differentially expressed in GSCs and described their association with GBM patient survival. We propose that these miRNAs participate on GSC features and could represent helpful prognostic markers and potential therapeutic targets in GBM.
ER -
ŠÁNA, Jiří, Petr BUŠEK, Pavel FADRUS, Andrej BEŠŠE, Lenka RADOVÁ, Marek VEČEŘA, Stefan REGULI, Lucie SROMOVA STOLLINOVA, Marek HILSER, Radim LIPINA, Radek LAKOMÝ, Leoš KŘEN, Martin SMRČKA, Aleksi ŠEDO and Ondřej SLABÝ. Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2018, vol.~8, FEB, p.~2836-2846. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-20929-6.
|
