DOBROTKOVÁ, Viera, Petr CHLAPEK, Pavel MAZÁNEK, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Traffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy. BMC Cancer. London: BioMed Central, 2018, vol. 18, No 1059, p. nestránkováno, 13 pp. ISSN 1471-2407. Available from: https://dx.doi.org/10.1186/s12885-018-4966-5. |
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@article{1490216, author = {Dobrotková, Viera and Chlapek, Petr and Mazánek, Pavel and Štěrba, Jaroslav and Veselská, Renata}, article_location = {London}, article_number = {1059}, doi = {http://dx.doi.org/10.1186/s12885-018-4966-5}, keywords = {Retinoids; cell differentiation; retinoid resistance; retinoid sensitivity; predictive biomarkers; acute myeloid leukemia; pancreatic ductal adenocarcinoma; breast carcinoma; neuroblastoma}, language = {eng}, issn = {1471-2407}, journal = {BMC Cancer}, title = {Traffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy}, url = {https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4966-5}, volume = {18}, year = {2018} }
TY - JOUR ID - 1490216 AU - Dobrotková, Viera - Chlapek, Petr - Mazánek, Pavel - Štěrba, Jaroslav - Veselská, Renata PY - 2018 TI - Traffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy JF - BMC Cancer VL - 18 IS - 1059 SP - nestránkováno EP - nestránkováno PB - BioMed Central SN - 14712407 KW - Retinoids KW - cell differentiation KW - retinoid resistance KW - retinoid sensitivity KW - predictive biomarkers KW - acute myeloid leukemia KW - pancreatic ductal adenocarcinoma KW - breast carcinoma KW - neuroblastoma UR - https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4966-5 L2 - https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4966-5 N2 - For decades, retinoids and their synthetic derivatives have been well established anticancer treatments due to their ability to regulate cell growth and induce cell differentiation and apoptosis. Many studies have reported the promising role of retinoids in attaining better outcomes for adult or pediatric patients suffering from several types of cancer, especially acute myeloid leukemia and neuroblastoma. However, even this promising differentiation therapy has some limitations: retinoid toxicity and intrinsic or acquired resistance have been observed in many patients. Therefore, the identification of molecular markers that predict the therapeutic response to retinoid treatment is undoubtedly important for retinoid use in clinical practice. The purpose of this review is to summarize the current knowledge on candidate markers, including both genetic alterations and protein markers, for retinoid resistance and sensitivity in human malignancies. ER -
DOBROTKOVÁ, Viera, Petr CHLAPEK, Pavel MAZÁNEK, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Traffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy. \textit{BMC Cancer}. London: BioMed Central, 2018, vol.~18, No~1059, p.~nestránkováno, 13 pp. ISSN~1471-2407. Available from: https://dx.doi.org/10.1186/s12885-018-4966-5.
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