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@article{1490257, author = {Kostolanská, Katarína and Peš, Ondřej and Zendulka, Ondřej and Máchal, Jan and Juřica, Jan}, article_number = {12}, doi = {http://dx.doi.org/10.1007/s11696-019-00682-4}, keywords = {Cytochrome P450; Phenotype; Lansoprazole; 5-Hydroxylansoprazole; Lansoprazole sulfone; Liquid chromatography; Mass spectrometry; Metabolites;}, language = {eng}, issn = {2585-7290}, journal = {Chemical Papers}, title = {Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping}, url = {https://link.springer.com/article/10.1007/s11696-019-00682-4#citeas}, volume = {73}, year = {2019} }
TY - JOUR ID - 1490257 AU - Kostolanská, Katarína - Peš, Ondřej - Zendulka, Ondřej - Máchal, Jan - Juřica, Jan PY - 2019 TI - Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping JF - Chemical Papers VL - 73 IS - 12 SP - 2955-2963 EP - 2955-2963 PB - Slovenská akadémia vied SN - 25857290 KW - Cytochrome P450 KW - Phenotype KW - Lansoprazole KW - 5-Hydroxylansoprazole KW - Lansoprazole sulfone KW - Liquid chromatography KW - Mass spectrometry KW - Metabolites; UR - https://link.springer.com/article/10.1007/s11696-019-00682-4#citeas L2 - https://link.springer.com/article/10.1007/s11696-019-00682-4#citeas N2 - A simple and sensitive liquid chromatography method with absorbance or mass spectrometry detection was developed and validated for the determination of lansoprazole, lansoprazole sulfone, and 5-hydroxylansorpazole in human serum with omeprazole as an internal standard. Analytes were, after an extraction step with a mixture of isopropyl alcohol: dichloromethane (2:8, v/v), separated in a gradient elution (acetonitrile: 20 mM ammonium formate) and detected at 280 and 300 nm or by monitoring selective reactions in a triple quadrupole mass analyzer. The limits of detection were, for all analytes, below 2 ng/mL and 3 pg/mL in the LC UV and LC MS method, respectively. The combined linear dynamic range exceeded 5 orders of magnitude. The method was successfully applied in the assessment of CYP2C19 and CYP3A4 metabolic phenotypes in ST-elevated myocardial infarction patients receiving novel anticoagulant treatment. ER -
KOSTOLANSKÁ, Katarína, Ondřej PEŠ, Ondřej ZENDULKA, Jan MÁCHAL and Jan JUŘICA. Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping. \textit{Chemical Papers}. Slovenská akadémia vied, 2019, vol.~73, No~12, p.~2955-2963. ISSN~2585-7290. Available from: https://dx.doi.org/10.1007/s11696-019-00682-4.
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