PATEL, M.B., Josef BEDNAŘÍK, P. LEE, Y. SHEHABI, J.I. SALLUH, A.J. SLOOTER, K.E. KLEIN, Y. SKROBIK, A. MORANDI, P.E. SPRONK, A.M. NAIDECH, B.T. PUN, F.A. BOZZA, A. MARRA, S. JOHN, P.P. PANDHARIPANDE and E.W. ELY. Delirium Monitoring in Neurocritically Ill Patients: A Systematic Review*. Critical Care Medicine. Philadelphia: Lippincott Williams & Wilkins, 2018, vol. 46, No 11, p. 1832-1841. ISSN 0090-3493. Available from: https://dx.doi.org/10.1097/CCM.0000000000003349.
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Basic information
Original name Delirium Monitoring in Neurocritically Ill Patients: A Systematic Review*
Authors PATEL, M.B. (840 United States of America), Josef BEDNAŘÍK (203 Czech Republic, guarantor, belonging to the institution), P. LEE (840 United States of America), Y. SHEHABI (36 Australia), J.I. SALLUH (76 Brazil), A.J. SLOOTER (528 Netherlands), K.E. KLEIN (840 United States of America), Y. SKROBIK (124 Canada), A. MORANDI (380 Italy), P.E. SPRONK (528 Netherlands), A.M. NAIDECH (840 United States of America), B.T. PUN (840 United States of America), F.A. BOZZA (76 Brazil), A. MARRA (840 United States of America), S. JOHN (840 United States of America), P.P. PANDHARIPANDE (840 United States of America) and E.W. ELY (840 United States of America).
Edition Critical Care Medicine, Philadelphia, Lippincott Williams & Wilkins, 2018, 0090-3493.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30218 General and internal medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 6.971
RIV identification code RIV/00216224:14740/18:00105951
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1097/CCM.0000000000003349
UT WoS 000447016100029
Keywords in English delirium; intensive care unit; neurocritical care; neurotrauma; stroke; traumatic brain injury
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 13/3/2019 11:14.
Abstract
Objectives: The Society of Critical Care Medicine recommends routine delirium monitoring, based on data in critically ill patients without primary neurologic injury. We sought to answer whether there are valid and reliable tools to monitor delirium in neurocritically ill patients and whether delirium is associated with relevant clinical outcomes (e.g., survival, length of stay, functional independence, cognition) in this population. Data Sources: We systematically reviewed Cumulative Index to Nursing and Allied Health Literature, Web of Science, and PubMed. Study Selection and Data Extraction: Inclusion criteria allowed any study design investigating delirium monitoring in neurocritically ill patients (e.g., neurotrauma, ischemic, and/or hemorrhagic stroke) of any age. We extracted data relevant to delirium tool sensitivity, specificity, negative predictive value, positive predictive value, interrater reliability, and associated clinical outcomes. Data Synthesis: Among seven prospective cohort studies and a total of 1,173 patients, delirium was assessed in neurocritically patients using validated delirium tools after considering primary neurologic diagnoses and associated complications, finding a pooled prevalence rate of 12-43%. When able to compare against a common reference standard, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, the test characteristics showed a sensitivity of 62-76%, specificity of 74-98%, positive predictive value of 63-91%, negative predictive value of 70-94%, and reliability kappa of 0.64-0.94. Among four studies reporting multivariable analyses, delirium in neurocritically patients was associated with increased hospital length of stay (n = 3) and ICU length of stay (n = 1), as well as worse functional independence (n = 1) and cognition (n = 2), but not survival. Conclusions: These data from studies of neurocritically ill patients demonstrate that patients with primary neurologic diagnoses can meet diagnostic criteria for delirium and that delirious features may predict relevant untoward clinical outcomes. There is a need for ongoing investigations regarding delirium in these complicated neurocritically ill patients.
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