DOUBKOVÁ, Martina, Jitka HAUSNEROVÁ, Ondřej VÝŠKA, Svatopluk RICHTER and Zdeněk MERTA. NECROTISING SARCOID GRANULOMATOSIS. A RARE GRANULOMATOUS DISEASE. Sarcoidosis Vasculitis and Diffuse Lung Diseases. Fidenza: Mattioli 1885, 2018, vol. 35, No 4, p. 395-398. ISSN 1124-0490.
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Basic information
Original name NECROTISING SARCOID GRANULOMATOSIS. A RARE GRANULOMATOUS DISEASE
Authors DOUBKOVÁ, Martina (203 Czech Republic, guarantor, belonging to the institution), Jitka HAUSNEROVÁ (203 Czech Republic), Ondřej VÝŠKA (203 Czech Republic), Svatopluk RICHTER (203 Czech Republic, belonging to the institution) and Zdeněk MERTA (203 Czech Republic, belonging to the institution).
Edition Sarcoidosis Vasculitis and Diffuse Lung Diseases, Fidenza, Mattioli 1885, 2018, 1124-0490.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30203 Respiratory systems
Country of publisher Italy
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.889
RIV identification code RIV/00216224:14110/18:00105961
Organization unit Faculty of Medicine
UT WoS 000452167600014
Keywords in English differential diagnosis; histopathological diagnosis; necrotising sarcoid granulomatosis
Tags 14110215, 14110216, rivok
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 10/2/2019 16:30.
Abstract
Introduction: Necrotizing sarcoid granulomatosis (NSG) is a very rare disease of unknown etiology characterized by sarcoid-like granulomas, vasculitis and necrosis in pulmonary and extrapulmonary localizations. Case report: We describe a case of a 34-year-old Caucasian male with fever, pleural pain, and nodular pulmonary opacities on chest radiograph. Histological examination of the lung tissue confirmed NSG. Diagnostically, infectious causes, vasculitis, and malignancy were excluded. A tendency to partial regression was observed, without the need for corticosteroid treatment. Conclusion: NSG is a rare disease which must be distinguished from other systemic diseases including vasculitides. The key to diagnosis, emphasized in our paper, is the histopathological finding. The course of NSG is similar to sarcoidosis. Corticosteroids are considered the treatment of choice, but the disease exhibits a tendency towards spontaneous regression.
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