Incidence of Hippocampal Metastases: Laterality and
Implications for Unilateral Hippocampal Avoiding Whole Brain
Radiotherapy

J 2018

Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy

KAZDA, Tomáš, Adela MISOVE, Petr BURKOŇ, Petr POSPÍŠIL, Ludmila HYNKOVÁ et. al.

Basic information

Original name

Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy

Authors

KAZDA, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Adela MISOVE (203 Czech Republic), Petr BURKOŇ (203 Czech Republic, belonging to the institution), Petr POSPÍŠIL (203 Czech Republic, belonging to the institution), Ludmila HYNKOVÁ (203 Czech Republic, belonging to the institution), Iveta SELINGEROVA (203 Czech Republic), Adam DZIACKY (703 Slovakia), Renata BELANOVÁ (203 Czech Republic), Martin BULIK (203 Czech Republic, belonging to the institution), Zdeněk ŘEHÁK (203 Czech Republic, belonging to the institution), Alexandr POPRACH (203 Czech Republic, belonging to the institution), Ondřej SLÁMA (203 Czech Republic, belonging to the institution), Pavel ŠLAMPA (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution), Radim JANČÁLEK (203 Czech Republic, belonging to the institution) and Radek LAKOMÝ (203 Czech Republic, belonging to the institution)

Edition

BioMed Research International, London, HINDAWI, 2018, 2314-6133

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.197

RIV identification code

RIV/00216224:14110/18:00105965

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1155/2018/2459608

UT WoS

000460311500001

Keywords in English

whole brain radiotherapy; Hippocampal metastases

Abstract

V originále

Introduction. Hippocampi sparing whole brain radiotherapy (WBRT) is an evolving approach in the treatment of patients with multiple brain metastases, pursuing mitigation of verbal memory decline as a consequence of hippocampal radiation injury. Accumulating data are showing different postradiotherapy changes in the left and right hippocampus with a theoretical proposal of only unilateral (dominant, left) hippocampal sparing during WBRT. Method. The aim of this retrospective study is to describe spatial distribution of brain metastases on MRI in a cohort of 260 patients (2595 metastases) and to evaluate distribution separately in the left and right hippocampus and in respective hippocampal avoiding zones (HAZ, region with subtherapeutic radiation dose), including evaluation of location of metastatic mass centre. Results. The median number of brain metastases was three, with lung cancer being the most common type of primary tumour; 36% had single metastasis. Almost 8% of patients had metastasis within hippocampus (1.1% of all metastases) and 18.1% of patients within HAZ (3.3% of all metastases). No statistically significant difference was observed in the laterality of hippocampal involvement, also when the location of centre of metastases was analyzed. There were more patients presenting the centre of metastasis within left (15) versus right (6) HAZ approaching the borderline of statistical significance. Conclusion. No significant difference in the laterality of BM seeding within hippocampal structures was observed. The hypothesized unilateral sparing WBRT would have theoretical advantage in about 50% reduction in the risk of subsequent recurrence within spared regions.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

NV18-03-00469, research and development project

Name: Reakce neuronální populace hipokampu na stereotaktickou radioterapii extratemporálních mozkových metastáz: vliv na neurokognitivní funkce a zachování kvality života

Investor: Ministry of Health of the CR

Citovat

KAZDA, Tomáš, Adela MISOVE, Petr BURKOŇ, Petr POSPÍŠIL, Ludmila HYNKOVÁ, Iveta SELINGEROVA, Adam DZIACKY, Renata BELANOVÁ, Martin BULIK, Zdeněk ŘEHÁK, Alexandr POPRACH, Ondřej SLÁMA, Pavel ŠLAMPA, Ondřej SLABÝ, Radim JANČÁLEK and Radek LAKOMÝ. Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy. BioMed Research International. London: HINDAWI, 2018, vol. 2018, No 2459608, p. 1-7. ISSN 2314-6133. Available from: https://dx.doi.org/10.1155/2018/2459608.

@article{1491957,
   author = {Kazda, Tomáš and Misove, Adela and Burkoň, Petr and Pospíšil, Petr and Hynková, Ludmila and Selingerova, Iveta and Dziacky, Adam and Belanová, Renata and Bulik, Martin and Řehák, Zdeněk and Poprach, Alexandr and Sláma, Ondřej and Šlampa, Pavel and Slabý, Ondřej and Jančálek, Radim and Lakomý, Radek},
   article_location = {London},
   article_number = {2459608},
   doi = {http://dx.doi.org/10.1155/2018/2459608},
   keywords = {whole brain radiotherapy; Hippocampal metastases},
   language = {eng},
   issn = {2314-6133},
   journal = {BioMed Research International},
   title = {Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy},
   volume = {2018},
   year = {2018}
}

TY  - JOUR
ID  - 1491957
AU  - Kazda, Tomáš - Misove, Adela - Burkoň, Petr - Pospíšil, Petr - Hynková, Ludmila - Selingerova, Iveta - Dziacky, Adam - Belanová, Renata - Bulik, Martin - Řehák, Zdeněk - Poprach, Alexandr - Sláma, Ondřej - Šlampa, Pavel - Slabý, Ondřej - Jančálek, Radim - Lakomý, Radek
PY  - 2018
TI  - Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy
JF  - BioMed Research International
VL  - 2018
IS  - 2459608
SP  - 1-7
EP  - 1-7
PB  - HINDAWI
SN  - 23146133
KW  - whole brain radiotherapy
KW  - Hippocampal metastases
N2  - Introduction. Hippocampi sparing whole brain radiotherapy (WBRT) is an evolving approach in the treatment of patients with multiple brain metastases, pursuing mitigation of verbal memory decline as a consequence of hippocampal radiation injury. Accumulating data are showing different postradiotherapy changes in the left and right hippocampus with a theoretical proposal of only unilateral (dominant, left) hippocampal sparing during WBRT. Method. The aim of this retrospective study is to describe spatial distribution of brain metastases on MRI in a cohort of 260 patients (2595 metastases) and to evaluate distribution separately in the left and right hippocampus and in respective hippocampal avoiding zones (HAZ, region with subtherapeutic radiation dose), including evaluation of location of metastatic mass centre. Results. The median number of brain metastases was three, with lung cancer being the most common type of primary tumour; 36% had single metastasis. Almost 8% of patients had metastasis within hippocampus (1.1% of all metastases) and 18.1% of patients within HAZ (3.3% of all metastases). No statistically significant difference was observed in the laterality of hippocampal involvement, also when the location of centre of metastases was analyzed. There were more patients presenting the centre of metastasis within left (15) versus right (6) HAZ approaching the borderline of statistical significance. Conclusion. No significant difference in the laterality of BM seeding within hippocampal structures was observed. The hypothesized unilateral sparing WBRT would have theoretical advantage in about 50% reduction in the risk of subsequent recurrence within spared regions.
ER  -

KAZDA, Tomáš, Adela MISOVE, Petr BURKOŇ, Petr POSPÍŠIL, Ludmila HYNKOVÁ, Iveta SELINGEROVA, Adam DZIACKY, Renata BELANOVÁ, Martin BULIK, Zdeněk ŘEHÁK, Alexandr POPRACH, Ondřej SLÁMA, Pavel ŠLAMPA, Ondřej SLABÝ, Radim JANČÁLEK and Radek LAKOMÝ. Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy. \textit{BioMed Research International}. London: HINDAWI, 2018, vol.~2018, No~2459608, p.~1-7. ISSN~2314-6133. Available from: https://dx.doi.org/10.1155/2018/2459608.

Detailed Information on Publication Record