| KAZDA, Tomáš, Adela MISOVE, Petr BURKOŇ, Petr POSPÍŠIL, Ludmila HYNKOVÁ, Iveta SELINGEROVA, Adam DZIACKY, Renata BELANOVÁ, Martin BULIK, Zdeněk ŘEHÁK, Alexandr POPRACH, Ondřej SLÁMA, Pavel ŠLAMPA, Ondřej SLABÝ, Radim JANČÁLEK and Radek LAKOMÝ. Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy. BioMed Research International. London: HINDAWI, 2018, vol. 2018, No 2459608, p. 1-7. ISSN 2314-6133. Available from: https://dx.doi.org/10.1155/2018/2459608. |
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@article{1491957,
author = {Kazda, Tomáš and Misove, Adela and Burkoň, Petr and Pospíšil, Petr and Hynková, Ludmila and Selingerova, Iveta and Dziacky, Adam and Belanová, Renata and Bulik, Martin and Řehák, Zdeněk and Poprach, Alexandr and Sláma, Ondřej and Šlampa, Pavel and Slabý, Ondřej and Jančálek, Radim and Lakomý, Radek},
article_location = {London},
article_number = {2459608},
doi = {http://dx.doi.org/10.1155/2018/2459608},
keywords = {whole brain radiotherapy; Hippocampal metastases},
language = {eng},
issn = {2314-6133},
journal = {BioMed Research International},
title = {Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy},
volume = {2018},
year = {2018}
}
TY - JOUR
ID - 1491957
AU - Kazda, Tomáš - Misove, Adela - Burkoň, Petr - Pospíšil, Petr - Hynková, Ludmila - Selingerova, Iveta - Dziacky, Adam - Belanová, Renata - Bulik, Martin - Řehák, Zdeněk - Poprach, Alexandr - Sláma, Ondřej - Šlampa, Pavel - Slabý, Ondřej - Jančálek, Radim - Lakomý, Radek
PY - 2018
TI - Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy
JF - BioMed Research International
VL - 2018
IS - 2459608
SP - 1-7
EP - 1-7
PB - HINDAWI
SN - 23146133
KW - whole brain radiotherapy
KW - Hippocampal metastases
N2 - Introduction. Hippocampi sparing whole brain radiotherapy (WBRT) is an evolving approach in the treatment of patients with multiple brain metastases, pursuing mitigation of verbal memory decline as a consequence of hippocampal radiation injury. Accumulating data are showing different postradiotherapy changes in the left and right hippocampus with a theoretical proposal of only unilateral (dominant, left) hippocampal sparing during WBRT. Method. The aim of this retrospective study is to describe spatial distribution of brain metastases on MRI in a cohort of 260 patients (2595 metastases) and to evaluate distribution separately in the left and right hippocampus and in respective hippocampal avoiding zones (HAZ, region with subtherapeutic radiation dose), including evaluation of location of metastatic mass centre. Results. The median number of brain metastases was three, with lung cancer being the most common type of primary tumour; 36% had single metastasis. Almost 8% of patients had metastasis within hippocampus (1.1% of all metastases) and 18.1% of patients within HAZ (3.3% of all metastases). No statistically significant difference was observed in the laterality of hippocampal involvement, also when the location of centre of metastases was analyzed. There were more patients presenting the centre of metastasis within left (15) versus right (6) HAZ approaching the borderline of statistical significance. Conclusion. No significant difference in the laterality of BM seeding within hippocampal structures was observed. The hypothesized unilateral sparing WBRT would have theoretical advantage in about 50% reduction in the risk of subsequent recurrence within spared regions.
ER -
KAZDA, Tomáš, Adela MISOVE, Petr BURKOŇ, Petr POSPÍŠIL, Ludmila HYNKOVÁ, Iveta SELINGEROVA, Adam DZIACKY, Renata BELANOVÁ, Martin BULIK, Zdeněk ŘEHÁK, Alexandr POPRACH, Ondřej SLÁMA, Pavel ŠLAMPA, Ondřej SLABÝ, Radim JANČÁLEK and Radek LAKOMÝ. Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy. \textit{BioMed Research International}. London: HINDAWI, 2018, vol.~2018, No~2459608, p.~1-7. ISSN~2314-6133. Available from: https://dx.doi.org/10.1155/2018/2459608.
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