Tumor grade as significant prognostic factor in pancreatic
cancer: validation of a novel TNMG staging system

J 2018

Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system

HLAVSA, Jan, F. CECKA, P. ZARUBA, J. ZAJAK, R. GURLICH et. al.

Basic information

Original name

Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system

Authors

HLAVSA, Jan (203 Czech Republic, belonging to the institution), F. CECKA (203 Czech Republic), P. ZARUBA (203 Czech Republic), J. ZAJAK (203 Czech Republic), R. GURLICH (203 Czech Republic), R. STRNAD (203 Czech Republic), Tomáš PAVLÍK (203 Czech Republic, belonging to the institution), Zdeněk KALA (203 Czech Republic, belonging to the institution) and M. LOVECEK (203 Czech Republic, guarantor)

Edition

Neoplasma, Bratislava, Slovenská akademie vied, 2018, 0028-2685

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.771

RIV identification code

RIV/00216224:14110/18:00106969

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.4149/neo_2018_171012N650

UT WoS

000440172400019

Keywords in English

pancreatic cancer; grade; TNM classification; prognosis

Abstract

V originále

Aim of the study was to asses the tumor grade prognostic value in the Czech pancreatic cancer patients and to evaluate the accuracy of TNMG prognostic model. Retrospective analysis of 431 pancreatic cancer patients undergoing pancreatic resection in seven Czech oncological centers between 2003 and 2013 was performed. The impact of tumor grade and the accuracy of TNMG prognostic model were evaluated. Lymph node status, tumor size, tumor stage and grade were proved as statistically significant survival predictors. The lower tumor differentiation (grade 3 and 4) was associated with poorer prognosis in all stages (stage I: HR 2.23 [1.14; 4.36, CI 95%] p=0.019, stage II: HR 3.09 [2.01; 4.77, CI 95%] p=0.001, stage III and IV: HR 3.52 [1.73; 7.18, CI 95%] p=0.001). Kaplan-Meier analysis verified statistically significant impact of new TNMG stages on survival after resection for pancreatic cancer (p=0.001). In conclusion, we can state that the tumor grade was confirmed as statistically significant prognostic factor in pancreatic cancer. Its incorporation into the current TNM classification enables more accurate prognosis prediction within particular clinical stages. That is why an inclusion of the grade to the standard TNM classification should be discussed.

Links

NV16-31314A, research and development project

Name: Identifikace cirkulujících mikroRNA umožňujících prognostickou stratifikaci a selekci pacientů nejvíce profitujících z chirurgické léčby

Citovat

HLAVSA, Jan, F. CECKA, P. ZARUBA, J. ZAJAK, R. GURLICH, R. STRNAD, Tomáš PAVLÍK, Zdeněk KALA and M. LOVECEK. Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system. Neoplasma. Bratislava: Slovenská akademie vied, 2018, vol. 65, No 4, p. 637-643. ISSN 0028-2685. Available from: https://dx.doi.org/10.4149/neo_2018_171012N650.

@article{1494147,
   author = {Hlavsa, Jan and Cecka, F. and Zaruba, P. and Zajak, J. and Gurlich, R. and Strnad, R. and Pavlík, Tomáš and Kala, Zdeněk and Lovecek, M.},
   article_location = {Bratislava},
   article_number = {4},
   doi = {http://dx.doi.org/10.4149/neo_2018_171012N650},
   keywords = {pancreatic cancer; grade; TNM classification; prognosis},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system},
   volume = {65},
   year = {2018}
}

TY  - JOUR
ID  - 1494147
AU  - Hlavsa, Jan - Cecka, F. - Zaruba, P. - Zajak, J. - Gurlich, R. - Strnad, R. - Pavlík, Tomáš - Kala, Zdeněk - Lovecek, M.
PY  - 2018
TI  - Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system
JF  - Neoplasma
VL  - 65
IS  - 4
SP  - 637-643
EP  - 637-643
PB  - Slovenská akademie vied
SN  - 00282685
KW  - pancreatic cancer
KW  - grade
KW  - TNM classification
KW  - prognosis
N2  - Aim of the study was to asses the tumor grade prognostic value in the Czech pancreatic cancer patients and to evaluate the accuracy of TNMG prognostic model. Retrospective analysis of 431 pancreatic cancer patients undergoing pancreatic resection in seven Czech oncological centers between 2003 and 2013 was performed. The impact of tumor grade and the accuracy of TNMG prognostic model were evaluated. Lymph node status, tumor size, tumor stage and grade were proved as statistically significant survival predictors. The lower tumor differentiation (grade 3 and 4) was associated with poorer prognosis in all stages (stage I: HR 2.23 [1.14; 4.36, CI 95%] p=0.019, stage II: HR 3.09 [2.01; 4.77, CI 95%] p=0.001, stage III and IV: HR 3.52 [1.73; 7.18, CI 95%] p=0.001). Kaplan-Meier analysis verified statistically significant impact of new TNMG stages on survival after resection for pancreatic cancer (p=0.001). In conclusion, we can state that the tumor grade was confirmed as statistically significant prognostic factor in pancreatic cancer. Its incorporation into the current TNM classification enables more accurate prognosis prediction within particular clinical stages. That is why an inclusion of the grade to the standard TNM classification should be discussed.
ER  -

HLAVSA, Jan, F. CECKA, P. ZARUBA, J. ZAJAK, R. GURLICH, R. STRNAD, Tomáš PAVLÍK, Zdeněk KALA and M. LOVECEK. Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2018, vol.~65, No~4, p.~637-643. ISSN~0028-2685. Available from: https://dx.doi.org/10.4149/neo\_{}2018\_{}171012N650.

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