Comparison of Active Substance Losses and Total Weight Losses
of Tablets Administered Via Feeding Tube

J 2019

Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube

PAPIEŽ, Adriána, Klara ODEHNALOVA, Vladimír ŠRÁMEK and Pavel SUK

Basic information

Original name

Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube

Authors

PAPIEŽ, Adriána (703 Slovakia, belonging to the institution), Klara ODEHNALOVA (203 Czech Republic), Vladimír ŠRÁMEK (203 Czech Republic, belonging to the institution) and Pavel SUK (203 Czech Republic, guarantor, belonging to the institution)

Edition

PHARMACOLOGY, BASEL, KARGER, 2019, 0031-7012

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.625

RIV identification code

RIV/00216224:14110/19:00109118

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1159/000496423

UT WoS

000464384500004

Keywords in English

Dosage forms; Drug administration routes; Nasogastric tube; Intensive care; High-pressure liquid chromatography

Abstract

V originále

Background/Aims: Administration of tablets via feeding tube (FT) is often associated with significant drug losses, as was confirmed by weighing. The aim of this study was to measure the proportion of active substance losses (ASLs) in an in vitro model. Methods: A film-coated tablet (FilmCT) containing clopidogrel (Trombex (R)) and a tablet with enteric coating (EntericCT) containing pantoprazole (Controloc (R)) were crushed in a mortar and transferred by method A (tablet powder was transferred into the beaker, poured into the syringe and water added) and method B (water was added into the mortar, suspension drawn into the syringe) and administered via FT in an in vitro model. Total losses were measured with analytical balance and, simultaneously, ASL were analyzed with high-performance liquid chromatography UV-detection (HPLC-UV). Results: ASL was different to weighing only in the case of EntericCT prepared by method B (2.0 +/- 4.2 and 10.7 +/- 0.8% for HPLC-UV and weighing, respectively; p = 0.004). HPLC-UV confirmed significantly lower ASL when method B was used for either EntericCT (34.3 +/- 7.2 vs. 2.0 +/- 4.2%; p < 0.001) or FilmCT (14.1 +/- 2.2 vs. 7.7 +/- 4.1%; p < 0.01). Conclusion: Drug loss analysis with analytical balance may overestimate ASL, as was proved for EntericCT in this study. ASL were significantly lower when method B was used.

Citovat

PAPIEŽ, Adriána, Klara ODEHNALOVA, Vladimír ŠRÁMEK and Pavel SUK. Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube. PHARMACOLOGY. BASEL: KARGER, 2019, vol. 103, 5-6, p. 246-249. ISSN 0031-7012. Available from: https://dx.doi.org/10.1159/000496423.

@article{1495596,
   author = {Papiež, Adriána and Odehnalova, Klara and Šrámek, Vladimír and Suk, Pavel},
   article_location = {BASEL},
   article_number = {5-6},
   doi = {http://dx.doi.org/10.1159/000496423},
   keywords = {Dosage forms; Drug administration routes; Nasogastric tube; Intensive care; High-pressure liquid chromatography},
   language = {eng},
   issn = {0031-7012},
   journal = {PHARMACOLOGY},
   title = {Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube},
   url = {https://www.karger.com/Article/FullText/496423},
   volume = {103},
   year = {2019}
}

TY  - JOUR
ID  - 1495596
AU  - Papiež, Adriána - Odehnalova, Klara - Šrámek, Vladimír - Suk, Pavel
PY  - 2019
TI  - Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube
JF  - PHARMACOLOGY
VL  - 103
IS  - 5-6
SP  - 246-249
EP  - 246-249
PB  - KARGER
SN  - 00317012
KW  - Dosage forms
KW  - Drug administration routes
KW  - Nasogastric tube
KW  - Intensive care
KW  - High-pressure liquid chromatography
UR  - https://www.karger.com/Article/FullText/496423
L2  - https://www.karger.com/Article/FullText/496423
N2  - Background/Aims: Administration of tablets via feeding tube (FT) is often associated with significant drug losses, as was confirmed by weighing. The aim of this study was to measure the proportion of active substance losses (ASLs) in an in vitro model. Methods: A film-coated tablet (FilmCT) containing clopidogrel (Trombex (R)) and a tablet with enteric coating (EntericCT) containing pantoprazole (Controloc (R)) were crushed in a mortar and transferred by method A (tablet powder was transferred into the beaker, poured into the syringe and water added) and method B (water was added into the mortar, suspension drawn into the syringe) and administered via FT in an in vitro model. Total losses were measured with analytical balance and, simultaneously, ASL were analyzed with high-performance liquid chromatography UV-detection (HPLC-UV). Results: ASL was different to weighing only in the case of EntericCT prepared by method B (2.0 +/- 4.2 and 10.7 +/- 0.8% for HPLC-UV and weighing, respectively; p = 0.004). HPLC-UV confirmed significantly lower ASL when method B was used for either EntericCT (34.3 +/- 7.2 vs. 2.0 +/- 4.2%; p < 0.001) or FilmCT (14.1 +/- 2.2 vs. 7.7 +/- 4.1%; p < 0.01). Conclusion: Drug loss analysis with analytical balance may overestimate ASL, as was proved for EntericCT in this study. ASL were significantly lower when method B was used.
ER  -

PAPIEŽ, Adriána, Klara ODEHNALOVA, Vladimír ŠRÁMEK and Pavel SUK. Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube. \textit{PHARMACOLOGY}. BASEL: KARGER, 2019, vol.~103, 5-6, p.~246-249. ISSN~0031-7012. Available from: https://dx.doi.org/10.1159/000496423.

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