Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube

PAPIEŽ, Adriána, Klara ODEHNALOVA, Vladimír ŠRÁMEK and Pavel SUK. Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube. PHARMACOLOGY. BASEL: KARGER, 2019, vol. 103, 5-6, p. 246-249. ISSN 0031-7012. Available from: https://dx.doi.org/10.1159/000496423.

Basic information

• Original name: Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube
• Authors: PAPIEŽ, Adriána (703 Slovakia, belonging to the institution), Klara ODEHNALOVA (203 Czech Republic), Vladimír ŠRÁMEK (203 Czech Republic, belonging to the institution) and Pavel SUK (203 Czech Republic, guarantor, belonging to the institution).
• Edition: PHARMACOLOGY, BASEL, KARGER, 2019, 0031-7012.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 1.625
• RIV identification code: RIV/00216224:14110/19:00109118
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1159/000496423
• UT WoS: 000464384500004
• Keywords in English: Dosage forms; Drug administration routes; Nasogastric tube; Intensive care; High-pressure liquid chromatography
• Tags: 14110122, rivok
• Tags: International impact, Reviewed

Abstract

Background/Aims: Administration of tablets via feeding tube (FT) is often associated with significant drug losses, as was confirmed by weighing. The aim of this study was to measure the proportion of active substance losses (ASLs) in an in vitro model. Methods: A film-coated tablet (FilmCT) containing clopidogrel (Trombex (R)) and a tablet with enteric coating (EntericCT) containing pantoprazole (Controloc (R)) were crushed in a mortar and transferred by method A (tablet powder was transferred into the beaker, poured into the syringe and water added) and method B (water was added into the mortar, suspension drawn into the syringe) and administered via FT in an in vitro model. Total losses were measured with analytical balance and, simultaneously, ASL were analyzed with high-performance liquid chromatography UV-detection (HPLC-UV). Results: ASL was different to weighing only in the case of EntericCT prepared by method B (2.0 +/- 4.2 and 10.7 +/- 0.8% for HPLC-UV and weighing, respectively; p = 0.004). HPLC-UV confirmed significantly lower ASL when method B was used for either EntericCT (34.3 +/- 7.2 vs. 2.0 +/- 4.2%; p < 0.001) or FilmCT (14.1 +/- 2.2 vs. 7.7 +/- 4.1%; p < 0.01). Conclusion: Drug loss analysis with analytical balance may overestimate ASL, as was proved for EntericCT in this study. ASL were significantly lower when method B was used.