STRÝČEK, Ondřej and Vladimír ŠRÁMEK. Nová definice status epilepticus a možnosti jeho farmakologické léčby (A new definition of status epilepticus and its pharmacological management). Anesteziologie a intenzivní medicína. Praha: Česká lékařská společnost J.E. Purkyně, 2018, vol. 29, No 4, p. 207-216. ISSN 1214-2158.
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Basic information
Original name Nová definice status epilepticus a možnosti jeho farmakologické léčby
Name in Czech Nová definice status epilepticus a možnosti jeho farmakologické léčby
Name (in English) A new definition of status epilepticus and its pharmacological management
Authors STRÝČEK, Ondřej (203 Czech Republic, guarantor, belonging to the institution) and Vladimír ŠRÁMEK (203 Czech Republic, belonging to the institution).
Edition Anesteziologie a intenzivní medicína, Praha, Česká lékařská společnost J.E. Purkyně, 2018, 1214-2158.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30223 Anaesthesiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/18:00106176
Organization unit Faculty of Medicine
UT WoS 000458867900006
Keywords (in Czech) status epilepticus, antiepileptika
Keywords in English Status epilepticus; definition; classification; therapy; antiepileptic drugs
Tags 14110122, 14110127, rivok
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 26/4/2019 16:22.
Abstract
Popsána deficnice status epilepticus, co nového přináší a jaké jsou možnosti jeho léčby.
Abstract (in English)
Status epilepticus is a life-threatening condition with a high mortality rate, requiring urgent therapy. To unify the views on this topic, a new definition has been proposed that reflects the patho-physiology better than the previous one. The new definition particularly highlights time as a major factor in the evolution of status epilepticus and points to the possibility of irreversible changes in the brain caused by the ongoing epileptic activity. The choice of a suitable drug is essential in treating status epilepticus. In addition to the traditional drugs (phenytoin, valproate), new drugs which promise significant benefits are emerging (levetiracetam, lacosamide). Some rescue treatment options (e.g. ketamine) are also mentioned. The choice of appropriately aggressive therapy is important. It is a common mistake to use one treatment guideline for all types of status epilepticus even though it does not fit the clinical picture and can even aggravate the patient's condition. Non-convulsive status epilepticus in particular requires a different approach.
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