Nová definice status epilepticus a možnosti jeho farmakologické léčby

STRÝČEK, Ondřej and Vladimír ŠRÁMEK. Nová definice status epilepticus a možnosti jeho farmakologické léčby (A new definition of status epilepticus and its pharmacological management). Anesteziologie a intenzivní medicína. Praha: Česká lékařská společnost J.E. Purkyně, 2018, vol. 29, No 4, p. 207-216. ISSN 1214-2158.

Basic information

Original name

Nová definice status epilepticus a možnosti jeho farmakologické léčby

Name in Czech

Nová definice status epilepticus a možnosti jeho farmakologické léčby

Name (in English)

A new definition of status epilepticus and its pharmacological management

Authors

STRÝČEK, Ondřej (203 Czech Republic, guarantor, belonging to the institution) and Vladimír ŠRÁMEK (203 Czech Republic, belonging to the institution)

Edition

Anesteziologie a intenzivní medicína, Praha, Česká lékařská společnost J.E. Purkyně, 2018, 1214-2158

---

Other information

Language

Czech

Type of outcome

Článek v odborném periodiku

Field of Study

30223 Anaesthesiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/18:00106176

Organization unit

Faculty of Medicine

UT WoS

000458867900006

Keywords (in Czech)

status epilepticus, antiepileptika

Keywords in English

Status epilepticus; definition; classification; therapy; antiepileptic drugs

Tags

14110122, 14110127, rivok

Tags

International impact, Reviewed

---

Abstract

V originále

Popsána deficnice status epilepticus, co nového přináší a jaké jsou možnosti jeho léčby.

In English

Status epilepticus is a life-threatening condition with a high mortality rate, requiring urgent therapy. To unify the views on this topic, a new definition has been proposed that reflects the patho-physiology better than the previous one. The new definition particularly highlights time as a major factor in the evolution of status epilepticus and points to the possibility of irreversible changes in the brain caused by the ongoing epileptic activity. The choice of a suitable drug is essential in treating status epilepticus. In addition to the traditional drugs (phenytoin, valproate), new drugs which promise significant benefits are emerging (levetiracetam, lacosamide). Some rescue treatment options (e.g. ketamine) are also mentioned. The choice of appropriately aggressive therapy is important. It is a common mistake to use one treatment guideline for all types of status epilepticus even though it does not fit the clinical picture and can even aggravate the patient's condition. Non-convulsive status epilepticus in particular requires a different approach.