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@article{1498162, author = {Škoda, Jan and Bořánková, Karolína and Jansson, Patric J. and Huang, Michael L.andH. and Veselská, Renata and Richardson, Desi Raymond}, article_location = {London}, article_number = {JAN}, doi = {http://dx.doi.org/10.1016/j.phrs.2018.11.020}, keywords = {Cancer stem cells; mitochondria; anti-cancer therapeutics; mitophagy; breast cancer; glioblastoma}, language = {eng}, issn = {1043-6618}, journal = {Pharmacological Research}, title = {Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies}, url = {https://www.sciencedirect.com/science/article/pii/S1043661818316049}, volume = {139}, year = {2019} }
TY - JOUR ID - 1498162 AU - Škoda, Jan - Bořánková, Karolína - Jansson, Patric J. - Huang, Michael L.-H. - Veselská, Renata - Richardson, Desi Raymond PY - 2019 TI - Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies JF - Pharmacological Research VL - 139 IS - JAN SP - 298-313 EP - 298-313 PB - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD SN - 10436618 KW - Cancer stem cells KW - mitochondria KW - anti-cancer therapeutics KW - mitophagy KW - breast cancer KW - glioblastoma UR - https://www.sciencedirect.com/science/article/pii/S1043661818316049 L2 - https://www.sciencedirect.com/science/article/pii/S1043661818316049 N2 - Mitochondria play vital roles in various cellular processes, ranging from cellular metabolism to signal transduction and cell death regulation. As these properties are critical for cancer growth, the mitochondrion has recently become an attractive target for anti-cancer therapies. In addition, it has come to light that mitochondria are crucially involved in the regulation of stem cell identity, differentiation and fate. A similar role for mitochondria has been also demonstrated in malignant stem-like cells termed cancer stem cells (CSCs), which are implicated in progression and resistance of many tumors. In this review, we summarize different mitochondrial functions reported to promote acquisition and maintenance of CSC phenotype and discuss the rationale for their therapeutic targeting. Particular emphasis is given to therapeutics that act directly through modulation of these mitochondrial functions and have recently emerged as promising anti-CSC drugs in pre-clinical studies. This review highlights the intriguing aspects of mitochondrial biology that may have a crucial role in cancer initiation, progression, and resistance and which might facilitate pharmacological targeting. Indeed, understanding of mitochondrial function in the regulation of CSCs will promote the development of novel CSC-targeted therapeutic strategies, which could significantly improve the long-term survival of cancer patients. ER -
ŠKODA, Jan, Karolína BOŘÁNKOVÁ, Patric J. JANSSON, Michael L.-H. HUANG, Renata VESELSKÁ a Desi Raymond RICHARDSON. Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies. \textit{Pharmacological Research}. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2019, roč.~139, JAN, s.~298-313. ISSN~1043-6618. Dostupné z: https://dx.doi.org/10.1016/j.phrs.2018.11.020.
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