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@article{1498162,
author = {Škoda, Jan and Bořánková, Karolína and Jansson, Patric J. and Huang, Michael L.andH. and Veselská, Renata and Richardson, Desi Raymond},
article_location = {London},
article_number = {JAN},
doi = {http://dx.doi.org/10.1016/j.phrs.2018.11.020},
keywords = {Cancer stem cells; mitochondria; anti-cancer therapeutics; mitophagy; breast cancer; glioblastoma},
language = {eng},
issn = {1043-6618},
journal = {Pharmacological Research},
title = {Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies},
url = {https://www.sciencedirect.com/science/article/pii/S1043661818316049},
volume = {139},
year = {2019}
}
TY - JOUR
ID - 1498162
AU - Škoda, Jan - Bořánková, Karolína - Jansson, Patric J. - Huang, Michael L.-H. - Veselská, Renata - Richardson, Desi Raymond
PY - 2019
TI - Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies
JF - Pharmacological Research
VL - 139
IS - JAN
SP - 298-313
EP - 298-313
PB - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
SN - 10436618
KW - Cancer stem cells
KW - mitochondria
KW - anti-cancer therapeutics
KW - mitophagy
KW - breast cancer
KW - glioblastoma
UR - https://www.sciencedirect.com/science/article/pii/S1043661818316049
L2 - https://www.sciencedirect.com/science/article/pii/S1043661818316049
N2 - Mitochondria play vital roles in various cellular processes, ranging from cellular metabolism to signal transduction and cell death regulation. As these properties are critical for cancer growth, the mitochondrion has recently become an attractive target for anti-cancer therapies. In addition, it has come to light that mitochondria are crucially involved in the regulation of stem cell identity, differentiation and fate. A similar role for mitochondria has been also demonstrated in malignant stem-like cells termed cancer stem cells (CSCs), which are implicated in progression and resistance of many tumors. In this review, we summarize different mitochondrial functions reported to promote acquisition and maintenance of CSC phenotype and discuss the rationale for their therapeutic targeting. Particular emphasis is given to therapeutics that act directly through modulation of these mitochondrial functions and have recently emerged as promising anti-CSC drugs in pre-clinical studies. This review highlights the intriguing aspects of mitochondrial biology that may have a crucial role in cancer initiation, progression, and resistance and which might facilitate pharmacological targeting. Indeed, understanding of mitochondrial function in the regulation of CSCs will promote the development of novel CSC-targeted therapeutic strategies, which could significantly improve the long-term survival of cancer patients.
ER -
ŠKODA, Jan, Karolína BOŘÁNKOVÁ, Patric J. JANSSON, Michael L.-H. HUANG, Renata VESELSKÁ and Desi Raymond RICHARDSON. Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies. \textit{Pharmacological Research}. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2019, vol.~139, JAN, p.~298-313. ISSN~1043-6618. Available from: https://dx.doi.org/10.1016/j.phrs.2018.11.020.
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