Natural selection in bats with historical exposure to
white-nose syndrome

J 2018

Natural selection in bats with historical exposure to white-nose syndrome

HARAZIM, Markéta, Ivan HORACEK, Lucie JAKEŠOVÁ, Kristína LUERMANN, Jiri C MORAVEC et. al.

Basic information

Original name

Natural selection in bats with historical exposure to white-nose syndrome

Authors

HARAZIM, Markéta (203 Czech Republic, belonging to the institution), Ivan HORACEK, Lucie JAKEŠOVÁ (203 Czech Republic, belonging to the institution), Kristína LUERMANN (703 Slovakia, belonging to the institution), Jiri C MORAVEC, Shannon MORGAN, Jiří PIKULA (203 Czech Republic), Petr SOSIK, Zuzana VAVRUSOVA, Alexandra Jr. ZAHRADNÍKOVÁ, Jan ZUKAL (203 Czech Republic, belonging to the institution) and Natália MARTÍNKOVÁ (703 Slovakia, guarantor, belonging to the institution)

Edition

BMC Zoology, London, BioMed Central, 2018, 2056-3132

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10602 Biology , Evolutionary biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Full Text

RIV identification code

RIV/00216224:14310/18:00109157

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1186/s40850-018-0035-4

UT WoS

000445835700001

Keywords in English

Skin; Fungal infection; Wound healing; Immunity; Gene evolution

Abstract

V originále

Hibernation allows animals to survive periods of resource scarcity by reducing their energy expenditure through decreased metabolism. However, hibernators become susceptible to psychrophilic pathogens if they cannot mount an efficient immune response to infection. While Nearctic bats infected with white-nose syndrome (WNS) suffer high mortality, related Palearctic taxa are better able to survive the disease than their Nearctic counterparts. We hypothesised that WNS exerted historical selective pressure in Palearctic bats, resulting in genomic changes that promote infection tolerance.Results: We investigated partial sequences of 23 genes related to water metabolism and skin structure function in nine Palearctic and Nearctic hibernating bat species and one non-hibernating species for phylogenetic signals of natural selection. Using maximum likelihood analysis, we found that eight genes were under positive selection and we successfully identified amino acid sites under selection in five encoded proteins. Branch site models revealed positive selection in three genes. Hibernating bats exhibit signals for positive selection in genes ensuring tissue regeneration, wound healing and modulation of the immune response.Conclusion: Our results highlight the importance of skin barrier integrity and healing capacity in hibernating bats. The protective role of skin integrity against both pathophysiology and WNS progression, in synergy with down regulation of the immune reaction in response to the Pseudogymnoascus destructans infection, improves host survival. Our data also suggest that hibernating bat species have evolved into tolerant hosts by reducing the negative impact of skin infection through a set of adaptations, including those at the genomic level.

Citovat

HARAZIM, Markéta, Ivan HORACEK, Lucie JAKEŠOVÁ, Kristína LUERMANN, Jiri C MORAVEC, Shannon MORGAN, Jiří PIKULA, Petr SOSIK, Zuzana VAVRUSOVA, Alexandra Jr. ZAHRADNÍKOVÁ, Jan ZUKAL and Natália MARTÍNKOVÁ. Natural selection in bats with historical exposure to white-nose syndrome. BMC Zoology. London: BioMed Central, 2018, vol. 3, AUG, p. 1-13. ISSN 2056-3132. Available from: https://dx.doi.org/10.1186/s40850-018-0035-4.

@article{1498336,
   author = {Harazim, Markéta and Horacek, Ivan and Jakešová, Lucie and Luermann, Kristína and Moravec, Jiri C and Morgan, Shannon and Pikula, Jiří and Sosik, Petr and Vavrusova, Zuzana and Zahradníková, Alexandra Jr. and Zukal, Jan and Martínková, Natália},
   article_location = {London},
   article_number = {AUG},
   doi = {http://dx.doi.org/10.1186/s40850-018-0035-4},
   keywords = {Skin; Fungal infection; Wound healing; Immunity; Gene evolution},
   language = {eng},
   issn = {2056-3132},
   journal = {BMC Zoology},
   title = {Natural selection in bats with historical exposure to white-nose syndrome},
   url = {https://bmczool.biomedcentral.com/articles/10.1186/s40850-018-0035-4},
   volume = {3},
   year = {2018}
}

TY  - JOUR
ID  - 1498336
AU  - Harazim, Markéta - Horacek, Ivan - Jakešová, Lucie - Luermann, Kristína - Moravec, Jiri C - Morgan, Shannon - Pikula, Jiří - Sosik, Petr - Vavrusova, Zuzana - Zahradníková, Alexandra Jr. - Zukal, Jan - Martínková, Natália
PY  - 2018
TI  - Natural selection in bats with historical exposure to white-nose syndrome
JF  - BMC Zoology
VL  - 3
IS  - AUG
SP  - 1-13
EP  - 1-13
PB  - BioMed Central
SN  - 20563132
KW  - Skin
KW  - Fungal infection
KW  - Wound healing
KW  - Immunity
KW  - Gene evolution
UR  - https://bmczool.biomedcentral.com/articles/10.1186/s40850-018-0035-4
L2  - https://bmczool.biomedcentral.com/articles/10.1186/s40850-018-0035-4
N2  - Hibernation allows animals to survive periods of resource scarcity by reducing their energy expenditure through decreased metabolism. However, hibernators become susceptible to psychrophilic pathogens if they cannot mount an efficient immune response to infection. While Nearctic bats infected with white-nose syndrome (WNS) suffer high mortality, related Palearctic taxa are better able to survive the disease than their Nearctic counterparts. We hypothesised that WNS exerted historical selective pressure in Palearctic bats, resulting in genomic changes that promote infection tolerance.Results: We investigated partial sequences of 23 genes related to water metabolism and skin structure function in nine Palearctic and Nearctic hibernating bat species and one non-hibernating species for phylogenetic signals of natural selection. Using maximum likelihood analysis, we found that eight genes were under positive selection and we successfully identified amino acid sites under selection in five encoded proteins. Branch site models revealed positive selection in three genes. Hibernating bats exhibit signals for positive selection in genes ensuring tissue regeneration, wound healing and modulation of the immune response.Conclusion: Our results highlight the importance of skin barrier integrity and healing capacity in hibernating bats. The protective role of skin integrity against both pathophysiology and WNS progression, in synergy with down regulation of the immune reaction in response to the Pseudogymnoascus destructans infection, improves host survival. Our data also suggest that hibernating bat species have evolved into tolerant hosts by reducing the negative impact of skin infection through a set of adaptations, including those at the genomic level.
ER  -

HARAZIM, Markéta, Ivan HORACEK, Lucie JAKEŠOVÁ, Kristína LUERMANN, Jiri C MORAVEC, Shannon MORGAN, Jiří PIKULA, Petr SOSIK, Zuzana VAVRUSOVA, Alexandra Jr. ZAHRADNÍKOVÁ, Jan ZUKAL and Natália MARTÍNKOVÁ. Natural selection in bats with historical exposure to white-nose syndrome. \textit{BMC Zoology}. London: BioMed Central, 2018, vol.~3, AUG, p.~1-13. ISSN~2056-3132. Available from: https://dx.doi.org/10.1186/s40850-018-0035-4.

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