Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese
Central-European Population

J 2018

Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population

HOŘÁK, Martin, Daniela KURUCZOVÁ, Filip ZLÁMAL, Josef TOMANDL, Julie DOBROVOLNÁ et. al.

Basic information

Original name

Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population

Authors

HOŘÁK, Martin (203 Czech Republic, guarantor, belonging to the institution), Daniela KURUCZOVÁ (703 Slovakia, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution) and Julie DOBROVOLNÁ (203 Czech Republic)

Edition

Disease Markers, London, Hindawi Publishing Corporation, 2018, 0278-0240

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30109 Pathology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.761

RIV identification code

RIV/00216224:14110/18:00106292

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1155/2018/4140815

UT WoS

000451854900001

Keywords in English

Follistatin-like 1

Abstract

V originále

Follistatin-like 1 (FSTL1) is a secreted adipomyokine with a possible link to obesity; however, its connection to extreme obesity currently remains unknown. In order to analyze such association for the very first time, we employed a unique cohort of morbidly and super obese individuals with a mean BMI of 44.77 kg/m(2) and measured the levels of circulating FSTL1. We explored the 3' UTR of FSTL1 to locate a genetic variant which impairs microRNA binding. We located and investigated such SNP (rs1057231) in relation to the FSTL1 protein level, obesity status, and other body composition parameters. We observed a significant decline in FSTL1 level in obese subjects in comparison to nonobese ones. The evaluated SNP was found to correlate with FSTL1 only in nonobese subjects. The presented results were not affected by sex since both males and females expressed FSTL1 equally. We suggest that the FSTL1 decrease observed in extremely obese subjects is a result of adipogenesis reduction accompanied by a senescence of preadipocytes which otherwise willingly express FSTL1, increased adipocyte apoptosis, and epigenetic FSTL1 silencing.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

HOŘÁK, Martin, Daniela KURUCZOVÁ, Filip ZLÁMAL, Josef TOMANDL and Julie DOBROVOLNÁ. Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population. Disease Markers. London: Hindawi Publishing Corporation, 2018, vol. 2018, No 4140815, p. 1-7. ISSN 0278-0240. Available from: https://dx.doi.org/10.1155/2018/4140815.

@article{1499640,
   author = {Hořák, Martin and Kuruczová, Daniela and Zlámal, Filip and Tomandl, Josef and Dobrovolná, Julie},
   article_location = {London},
   article_number = {4140815},
   doi = {http://dx.doi.org/10.1155/2018/4140815},
   keywords = {Follistatin-like 1},
   language = {eng},
   issn = {0278-0240},
   journal = {Disease Markers},
   title = {Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population},
   volume = {2018},
   year = {2018}
}

TY  - JOUR
ID  - 1499640
AU  - Hořák, Martin - Kuruczová, Daniela - Zlámal, Filip - Tomandl, Josef - Dobrovolná, Julie
PY  - 2018
TI  - Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population
JF  - Disease Markers
VL  - 2018
IS  - 4140815
SP  - 1-7
EP  - 1-7
PB  - Hindawi Publishing Corporation
SN  - 02780240
KW  - Follistatin-like 1
N2  - Follistatin-like 1 (FSTL1) is a secreted adipomyokine with a possible link to obesity; however, its connection to extreme obesity currently remains unknown. In order to analyze such association for the very first time, we employed a unique cohort of morbidly and super obese individuals with a mean BMI of 44.77 kg/m(2) and measured the levels of circulating FSTL1. We explored the 3' UTR of FSTL1 to locate a genetic variant which impairs microRNA binding. We located and investigated such SNP (rs1057231) in relation to the FSTL1 protein level, obesity status, and other body composition parameters. We observed a significant decline in FSTL1 level in obese subjects in comparison to nonobese ones. The evaluated SNP was found to correlate with FSTL1 only in nonobese subjects. The presented results were not affected by sex since both males and females expressed FSTL1 equally. We suggest that the FSTL1 decrease observed in extremely obese subjects is a result of adipogenesis reduction accompanied by a senescence of preadipocytes which otherwise willingly express FSTL1, increased adipocyte apoptosis, and epigenetic FSTL1 silencing.
ER  -

HOŘÁK, Martin, Daniela KURUCZOVÁ, Filip ZLÁMAL, Josef TOMANDL and Julie DOBROVOLNÁ. Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population. \textit{Disease Markers}. London: Hindawi Publishing Corporation, 2018, vol.~2018, No~4140815, p.~1-7. ISSN~0278-0240. Available from: https://dx.doi.org/10.1155/2018/4140815.

Detailed Information on Publication Record