J 2018

Neovascularization after ischemic conditioning of the stomach and the influence of follow-up neoadjuvant chemotherapy thereon

PRUDIUS, Vadim, Vladimír PROCHÁZKA, Zdeněk PAVLOVSKÝ, Adam PEŠTÁL, Petr VLČEK et. al.

Basic information

Original name

Neovascularization after ischemic conditioning of the stomach and the influence of follow-up neoadjuvant chemotherapy thereon

Authors

PRUDIUS, Vadim (203 Czech Republic, guarantor, belonging to the institution), Vladimír PROCHÁZKA (203 Czech Republic), Zdeněk PAVLOVSKÝ (203 Czech Republic), Adam PEŠTÁL (203 Czech Republic, belonging to the institution), Petr VLČEK (203 Czech Republic, belonging to the institution), Ivan ČAPOV (203 Czech Republic, belonging to the institution), Lenka VEVERKOVÁ (203 Czech Republic, belonging to the institution) and Michal REŠKA (203 Czech Republic, belonging to the institution)

Edition

VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES, POZNAN, TERMEDIA PUBLISHING HOUSE LTD, 2018, 1895-4588

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30212 Surgery

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.147

RIV identification code

RIV/00216224:14110/18:00106369

Organization unit

Faculty of Medicine

DOI

UT WoS

000443453800004

Keywords in English

esophageal cancer; neovascularization; esophageal surgery; gastric conduit; ischemic conditioning

Tags

Tags

International impact, Reviewed
Změněno: 27/2/2019 12:07, Soňa Böhmová

Abstract

V originále

Introduction: Esophagectomy and reconstruction remain the optimal treatment for patients with resectable esophageal cancer. Neovascularization after ischemic conditioning of the stomach before esophagectomy is a laparoscopic procedure which may potentially reduce gastric conduit ischemia. Aim: To investigate the influence of ischemic conditioning on neovascularization along the greater curvature of the stomach and to explore the effect of neoadjuvant chemotherapy on neovascularization after ischemic conditioning. Material and methods: Staging laparoscopy was performed before the main resection procedure; during this procedure ischemic conditioning was performed. Samples taken from the human stomach were divided into 3 groups: group A - patients after ischemic conditioning with a delay of 30-45 days after left gastric artery (LGA) ligation (n = 4); group B - patients who were undergoing neoadjuvant chemotherapy with a delay of 90-140 days after left gastric artery ligation (n = 4); and control group C- patients without ischemic conditioning (n = 7). Results: After ischemic conditioning with a delay of 30-45 days, the count of neovessels along the greater curvature of the stomach increased from 5.4 +/- 0.7 in the control group to 17.5 +/- 0.9 in a low-power field of view (LPF) in group A and increased still further on average to 19.8 +/- 10.4 in group B. Conclusions: Left gastric artery ligation only is a sufficient procedure for ischemic conditioning of the stomach. Neovascularization along the greater curvature is a continuous process that depends on delay time. Neoadjuvant therapy has no influence on the effect of neovascularization.