| PRUDIUS, Vadim, Vladimír PROCHÁZKA, Zdeněk PAVLOVSKÝ, Adam PEŠTÁL, Petr VLČEK, Ivan ČAPOV, Lenka VEVERKOVÁ and Michal REŠKA. Neovascularization after ischemic conditioning of the stomach and the influence of follow-up neoadjuvant chemotherapy thereon. VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES. POZNAN: TERMEDIA PUBLISHING HOUSE LTD, 2018, vol. 13, No 3, p. 299-305. ISSN 1895-4588. Available from: https://dx.doi.org/10.5114/wiitm.2018.75907. |
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@article{1501457,
author = {Prudius, Vadim and Procházka, Vladimír and Pavlovský, Zdeněk and Peštál, Adam and Vlček, Petr and Čapov, Ivan and Veverková, Lenka and Reška, Michal},
article_location = {POZNAN},
article_number = {3},
doi = {http://dx.doi.org/10.5114/wiitm.2018.75907},
keywords = {esophageal cancer; neovascularization; esophageal surgery; gastric conduit; ischemic conditioning},
language = {eng},
issn = {1895-4588},
journal = {VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES},
title = {Neovascularization after ischemic conditioning of the stomach and the influence of follow-up neoadjuvant chemotherapy thereon},
volume = {13},
year = {2018}
}
TY - JOUR
ID - 1501457
AU - Prudius, Vadim - Procházka, Vladimír - Pavlovský, Zdeněk - Peštál, Adam - Vlček, Petr - Čapov, Ivan - Veverková, Lenka - Reška, Michal
PY - 2018
TI - Neovascularization after ischemic conditioning of the stomach and the influence of follow-up neoadjuvant chemotherapy thereon
JF - VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
VL - 13
IS - 3
SP - 299-305
EP - 299-305
PB - TERMEDIA PUBLISHING HOUSE LTD
SN - 18954588
KW - esophageal cancer
KW - neovascularization
KW - esophageal surgery
KW - gastric conduit
KW - ischemic conditioning
N2 - Introduction: Esophagectomy and reconstruction remain the optimal treatment for patients with resectable esophageal cancer. Neovascularization after ischemic conditioning of the stomach before esophagectomy is a laparoscopic procedure which may potentially reduce gastric conduit ischemia. Aim: To investigate the influence of ischemic conditioning on neovascularization along the greater curvature of the stomach and to explore the effect of neoadjuvant chemotherapy on neovascularization after ischemic conditioning. Material and methods: Staging laparoscopy was performed before the main resection procedure; during this procedure ischemic conditioning was performed. Samples taken from the human stomach were divided into 3 groups: group A - patients after ischemic conditioning with a delay of 30-45 days after left gastric artery (LGA) ligation (n = 4); group B - patients who were undergoing neoadjuvant chemotherapy with a delay of 90-140 days after left gastric artery ligation (n = 4); and control group C- patients without ischemic conditioning (n = 7). Results: After ischemic conditioning with a delay of 30-45 days, the count of neovessels along the greater curvature of the stomach increased from 5.4 +/- 0.7 in the control group to 17.5 +/- 0.9 in a low-power field of view (LPF) in group A and increased still further on average to 19.8 +/- 10.4 in group B. Conclusions: Left gastric artery ligation only is a sufficient procedure for ischemic conditioning of the stomach. Neovascularization along the greater curvature is a continuous process that depends on delay time. Neoadjuvant therapy has no influence on the effect of neovascularization.
ER -
PRUDIUS, Vadim, Vladimír PROCHÁZKA, Zdeněk PAVLOVSKÝ, Adam PEŠTÁL, Petr VLČEK, Ivan ČAPOV, Lenka VEVERKOVÁ and Michal REŠKA. Neovascularization after ischemic conditioning of the stomach and the influence of follow-up neoadjuvant chemotherapy thereon. \textit{VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES}. POZNAN: TERMEDIA PUBLISHING HOUSE LTD, 2018, vol.~13, No~3, p.~299-305. ISSN~1895-4588. Available from: https://dx.doi.org/10.5114/wiitm.2018.75907.
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