| MAZURENKO, Stanislav, Jan ŠTOURAČ, Antonín KUNKA, S. NEDELJKOVIC, David BEDNÁŘ, Zbyněk PROKOP and Jiří DAMBORSKÝ. CalFitter: a web server for analysis of protein thermal denaturation data. Nucleic Acids Research. Oxford: Oxford University Press, 2018, vol. 46, W1, p. "W344"-"W349", 6 pp. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gky358. |
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@article{1503349,
author = {Mazurenko, Stanislav and Štourač, Jan and Kunka, Antonín and Nedeljkovic, S. and Bednář, David and Prokop, Zbyněk and Damborský, Jiří},
article_location = {Oxford},
article_number = {W1},
doi = {http://dx.doi.org/10.1093/nar/gky358},
keywords = {DIFFERENTIAL SCANNING CALORIMETRY; THEORETICAL-ANALYSIS; STABILITY; STATE; TEMPERATURE; 3-STATE; ENZYME; RATES},
language = {eng},
issn = {0305-1048},
journal = {Nucleic Acids Research},
title = {CalFitter: a web server for analysis of protein thermal denaturation data},
url = {https://loschmidt.chemi.muni.cz/peg/category/publications/#2018},
volume = {46},
year = {2018}
}
TY - JOUR
ID - 1503349
AU - Mazurenko, Stanislav - Štourač, Jan - Kunka, Antonín - Nedeljkovic, S. - Bednář, David - Prokop, Zbyněk - Damborský, Jiří
PY - 2018
TI - CalFitter: a web server for analysis of protein thermal denaturation data
JF - Nucleic Acids Research
VL - 46
IS - W1
SP - "W344"-"W349"
EP - "W344"-"W349"
PB - Oxford University Press
SN - 03051048
KW - DIFFERENTIAL SCANNING CALORIMETRY
KW - THEORETICAL-ANALYSIS
KW - STABILITY
KW - STATE
KW - TEMPERATURE
KW - 3-STATE
KW - ENZYME
KW - RATES
UR - https://loschmidt.chemi.muni.cz/peg/category/publications/#2018
N2 - Despite significant advances in the understanding of protein structure-function relationships, revealing protein folding pathways still poses a challenge due to a limited number of relevant experimental tools. Widely-used experimental techniques, such as calorimetry or spectroscopy, critically depend on a proper data analysis. Currently, there are only separate data analysis tools available for each type of experiment with a limited model selection. To address this problem, we have developed the CalFitter web server to be a unified platform for comprehensive data fitting and analysis of protein thermal denaturation data. The server allows simultaneous global data fitting using any combination of input data types and offers 12 protein unfolding pathway models for selection, including irreversible transitions often missing from other tools. The data fitting produces optimal parameter values, their confidence intervals, and statistical information to define unfolding pathways. The server provides an interactive and easy-to-use interface that allows users to directly analyse input datasets and simulate modelled output based on the model parameters.
ER -
MAZURENKO, Stanislav, Jan ŠTOURAČ, Antonín KUNKA, S. NEDELJKOVIC, David BEDNÁŘ, Zbyněk PROKOP and Jiří DAMBORSKÝ. CalFitter: a web server for analysis of protein thermal denaturation data. \textit{Nucleic Acids Research}. Oxford: Oxford University Press, 2018, vol.~46, W1, p.~''W344''-''W349'', 6 pp. ISSN~0305-1048. Available from: https://dx.doi.org/10.1093/nar/gky358.
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