Detailed Information on Publication Record
2018
Identification of candidate genes underlying soft tissue sarcoma progression using a progression series of murine fibrosarcoma cell lines
HATINA, J., M. KRIPNEROVA, H.S. PARMAR, Z. HOUDEK, P. DVORAK et. al.Basic information
Original name
Identification of candidate genes underlying soft tissue sarcoma progression using a progression series of murine fibrosarcoma cell lines
Authors
HATINA, J. (203 Czech Republic), M. KRIPNEROVA (203 Czech Republic), H.S. PARMAR (203 Czech Republic), Z. HOUDEK (203 Czech Republic), P. DVORAK (203 Czech Republic), K. HOUFKOVA (203 Czech Republic), M. PESTA (203 Czech Republic), J. KUNCOVA (203 Czech Republic), Jiří ŠÁNA (203 Czech Republic, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)
Edition
25th Biennial Congress of the European Association for Cancer Research, 2018
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
10608 Biochemistry and molecular biology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.959
RIV identification code
RIV/00216224:14740/18:00101758
Organization unit
Central European Institute of Technology
ISSN
UT WoS
000437674104052
Keywords in English
soft tissue sarcoma; murine fibrosarcoma
Tags
Tags
International impact, Reviewed
Změněno: 5/3/2019 09:52, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
ntroduction Soft tissue sarcomas are known for their great variability in clinical behaviour, ranging from almost indolent lesions to rapidly metastasing tumours. Genes responsible for sarcoma progression have been poorly characterised by now. Towards this end, we established a unique single-background progression series of murine sarcoma cell lines, consisting of the slowly proliferating nonmotile and noninvasive cell line JUN-2, rapidly proliferating, motile and invasive cell line JUN-3, and the cell line JUN-2fos-3 that exhibits a unique transformation pattern, with little deregulation of cell growth and proliferation, but pronounced motility and invasiveness.
Links
| GA17-17636S, research and development project |
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