Other formats:
BibTeX
LaTeX
RIS
@inbook{1503433, author = {Brezovský, Jan and Kozlíková, Barbora and Damborský, Jiří}, address = {New York}, booktitle = {PROTEIN ENGINEERING. METHODS AND PROTOCOLS}, editor = {Editors: Bornscheuer, Uwe T., Höhne, Matthias}, keywords = {Binding; Protein; Tunnel; Channel; Gate; Rational design; Software; CAVER; Transport}, howpublished = {tištěná verze "print"}, language = {eng}, location = {New York}, isbn = {978-1-4939-7366-8}, pages = {25-42}, publisher = {Springer}, title = {Computational Analysis of Protein Tunnels and Channels}, url = {https://loschmidt.chemi.muni.cz/peg/wp-content/uploads/2017/11/book17_brezovsky.pdf}, year = {2017} }
TY - CHAP ID - 1503433 AU - Brezovský, Jan - Kozlíková, Barbora - Damborský, Jiří PY - 2017 TI - Computational Analysis of Protein Tunnels and Channels VL - neuveden pro RIV PB - Springer CY - New York SN - 9781493973668 KW - Binding KW - Protein KW - Tunnel KW - Channel KW - Gate KW - Rational design KW - Software KW - CAVER KW - Transport UR - https://loschmidt.chemi.muni.cz/peg/wp-content/uploads/2017/11/book17_brezovsky.pdf N2 - Protein tunnels connecting the functional buried cavities with bulk solvent and protein channels, enabling the transport through biological membranes, represent the structural features that govern the exchange rates of ligands, ions, and water solvent. Tunnels and channels are present in a vast number of known proteins and provide control over their function. Modification of these structural features by protein engineering frequently provides proteins with improved properties. Here we present a detailed computational protocol employing the CAVER software that is applicable for: (1) the analysis of tunnels and channels in protein structures, and (2) the selection of hot-spot residues in tunnels or channels that can be mutagenized for improved activity, specificity, enantioselectivity, or stability ER -
BREZOVSKÝ, Jan, Barbora KOZLÍKOVÁ and Jiří DAMBORSKÝ. Computational Analysis of Protein Tunnels and Channels. In Editors: Bornscheuer, Uwe T., Höhne, Matthias. \textit{PROTEIN ENGINEERING. METHODS AND PROTOCOLS}. New York: Springer, 2017, p.~25-42. ISBN~978-1-4939-7366-8.
|