High c-Myb Expression Associates with Good Prognosis in
Colorectal Carcinoma

J 2019

High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma

TICHÝ, Michal, Lucia KNOPFOVÁ, Jiří JARKOVSKÝ, Petr VLČEK, Jana KATOLICKÁ et. al.

Basic information

Original name

High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma

Authors

TICHÝ, Michal (203 Czech Republic, belonging to the institution), Lucia KNOPFOVÁ (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Petr VLČEK (203 Czech Republic), Jana KATOLICKÁ (203 Czech Republic), Ivan ČAPOV (203 Czech Republic), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Jan ŠMARDA (203 Czech Republic, belonging to the institution) and Petr BENEŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Cancer, Australia, IVYSPRING INT PUBL, 2019, 1837-9664

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Australia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.565

RIV identification code

RIV/00216224:14310/19:00107306

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.7150/jca.29530

UT WoS

000459711200007

Keywords in English

c-Myb; colorectal cancer; prognosis; survival

Abstract

V originále

Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expression of c-Myb protein, determined by immunohistochemistry (IHC), associates with better overall and disease-free survival (OS, DFS) in a cohort of 103 patients. Although MYB has been previously considered to act as oncogene in CRC, our further analysis of datasets deposited in PrognoScan and SurvExpress databases confirmed that high MYB expression largely associates with good prognosis in CRC. As therapies targeting c-Myb have been developed and tested in preclinical studies, we believe that further studies are needed for detailed understanding of c-Myb function in CRC, before the c-Myb-targeted therapy enters clinical trials.

Links

GJ17-08985Y, research and development project

Name: Prozánětlivá signalizace pod kontrolou proteinu c-Myb v bazálních prsních karcinomech

Investor: Czech Science Foundation

NV18-07-00073, research and development project

Name: c-Myb a jeho transkripční program ve fyziologických a patologických osteogenních procesech

Investor: Ministry of Health of the CR

Citovat

TICHÝ, Michal, Lucia KNOPFOVÁ, Jiří JARKOVSKÝ, Petr VLČEK, Jana KATOLICKÁ, Ivan ČAPOV, Markéta HERMANOVÁ, Jan ŠMARDA and Petr BENEŠ. High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma. Journal of Cancer. Australia: IVYSPRING INT PUBL, 2019, vol. 10, No 6, p. 1393-1397. ISSN 1837-9664. Available from: https://dx.doi.org/10.7150/jca.29530.

@article{1503876,
   author = {Tichý, Michal and Knopfová, Lucia and Jarkovský, Jiří and Vlček, Petr and Katolická, Jana and Čapov, Ivan and Hermanová, Markéta and Šmarda, Jan and Beneš, Petr},
   article_location = {Australia},
   article_number = {6},
   doi = {http://dx.doi.org/10.7150/jca.29530},
   keywords = {c-Myb; colorectal cancer; prognosis; survival},
   language = {eng},
   issn = {1837-9664},
   journal = {Journal of Cancer},
   title = {High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma},
   url = {http://www.jcancer.org/v10p1393.htm},
   volume = {10},
   year = {2019}
}

TY  - JOUR
ID  - 1503876
AU  - Tichý, Michal - Knopfová, Lucia - Jarkovský, Jiří - Vlček, Petr - Katolická, Jana - Čapov, Ivan - Hermanová, Markéta - Šmarda, Jan - Beneš, Petr
PY  - 2019
TI  - High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma
JF  - Journal of Cancer
VL  - 10
IS  - 6
SP  - 1393-1397
EP  - 1393-1397
PB  - IVYSPRING INT PUBL
SN  - 18379664
KW  - c-Myb
KW  - colorectal cancer
KW  - prognosis
KW  - survival
UR  - http://www.jcancer.org/v10p1393.htm
L2  - http://www.jcancer.org/v10p1393.htm
N2  - Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expression of c-Myb protein, determined by immunohistochemistry (IHC), associates with better overall and disease-free survival (OS, DFS) in a cohort of 103 patients. Although MYB has been previously considered to act as oncogene in CRC, our further analysis of datasets deposited in PrognoScan and SurvExpress databases confirmed that high MYB expression largely associates with good prognosis in CRC. As therapies targeting c-Myb have been developed and tested in preclinical studies, we believe that further studies are needed for detailed understanding of c-Myb function in CRC, before the c-Myb-targeted therapy enters clinical trials.
ER  -

TICHÝ, Michal, Lucia KNOPFOVÁ, Jiří JARKOVSKÝ, Petr VLČEK, Jana KATOLICKÁ, Ivan ČAPOV, Markéta HERMANOVÁ, Jan ŠMARDA and Petr BENEŠ. High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma. \textit{Journal of Cancer}. Australia: IVYSPRING INT PUBL, 2019, vol.~10, No~6, p.~1393-1397. ISSN~1837-9664. Available from: https://dx.doi.org/10.7150/jca.29530.

Detailed Information on Publication Record