Other formats:
BibTeX
LaTeX
RIS
@article{1503876, author = {Tichý, Michal and Knopfová, Lucia and Jarkovský, Jiří and Vlček, Petr and Katolická, Jana and Čapov, Ivan and Hermanová, Markéta and Šmarda, Jan and Beneš, Petr}, article_location = {Australia}, article_number = {6}, doi = {http://dx.doi.org/10.7150/jca.29530}, keywords = {c-Myb; colorectal cancer; prognosis; survival}, language = {eng}, issn = {1837-9664}, journal = {Journal of Cancer}, title = {High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma}, url = {http://www.jcancer.org/v10p1393.htm}, volume = {10}, year = {2019} }
TY - JOUR ID - 1503876 AU - Tichý, Michal - Knopfová, Lucia - Jarkovský, Jiří - Vlček, Petr - Katolická, Jana - Čapov, Ivan - Hermanová, Markéta - Šmarda, Jan - Beneš, Petr PY - 2019 TI - High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma JF - Journal of Cancer VL - 10 IS - 6 SP - 1393-1397 EP - 1393-1397 PB - IVYSPRING INT PUBL SN - 18379664 KW - c-Myb KW - colorectal cancer KW - prognosis KW - survival UR - http://www.jcancer.org/v10p1393.htm L2 - http://www.jcancer.org/v10p1393.htm N2 - Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expression of c-Myb protein, determined by immunohistochemistry (IHC), associates with better overall and disease-free survival (OS, DFS) in a cohort of 103 patients. Although MYB has been previously considered to act as oncogene in CRC, our further analysis of datasets deposited in PrognoScan and SurvExpress databases confirmed that high MYB expression largely associates with good prognosis in CRC. As therapies targeting c-Myb have been developed and tested in preclinical studies, we believe that further studies are needed for detailed understanding of c-Myb function in CRC, before the c-Myb-targeted therapy enters clinical trials. ER -
TICHÝ, Michal, Lucia KNOPFOVÁ, Jiří JARKOVSKÝ, Petr VLČEK, Jana KATOLICKÁ, Ivan ČAPOV, Markéta HERMANOVÁ, Jan ŠMARDA and Petr BENEŠ. High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma. \textit{Journal of Cancer}. Australia: IVYSPRING INT PUBL, 2019, vol.~10, No~6, p.~1393-1397. ISSN~1837-9664. Available from: https://dx.doi.org/10.7150/jca.29530.
|