Comparative analysis of high butanol tolerance and production
in clostridia

J 2018

Comparative analysis of high butanol tolerance and production in clostridia

PATAKOVA, Petra, Jan KOLEK, Karel SEDLAR, Pavlina KOSCOVA, Barbora BRANSKA et. al.

Basic information

Original name

Comparative analysis of high butanol tolerance and production in clostridia

Authors

PATAKOVA, Petra (203 Czech Republic, guarantor), Jan KOLEK (203 Czech Republic), Karel SEDLAR (203 Czech Republic), Pavlina KOSCOVA (203 Czech Republic), Barbora BRANSKA (203 Czech Republic), Kristyna KUPKOVA (203 Czech Republic), Leona PAULOVA (203 Czech Republic) and Ivo PROVAZNÍK (203 Czech Republic, belonging to the institution)

Edition

BIOTECHNOLOGY ADVANCES, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2018, 0734-9750

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 12.831

RIV identification code

RIV/00216224:14110/18:00106536

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.biotechadv.2017.12.004

UT WoS

000432104800013

Keywords in English

Clostridium; ABE fermentation; Butanol tolerance; Butanol production; Genome mining; Transcriptomics

Abstract

V originále

2016, was the 100 years anniversary from launching of the first industrial acetone-butanol-ethanol (ABE) microbial production process. Despite this long period and also revival of scientific interest in this fermentative process over the last 20 years, solventogenic clostridia, mainly Clostridium acetobutylicum, Clostridium beijerinckii, Clostridium saccharoperbutylacetonicum and Clostridium pasteurianum, still have most of their secrets. One such poorly understood mechanism is butanol tolerance, which seems to be one of the most significant bottlenecks obstructing industrial exploitation of the process because the maximum achievable butanol concentration is only about 21 g/L. This review describes all the known cellular responses elicited by butanol, such as modifications of cell membrane and cell wall, formation of stress proteins, extrusion of butanol by efflux pumps, response of regulatory pathways, and also maps both random and targeted mutations resulting in high butanol production phenotypes. As progress in the field is inseparably associated with emerging methods, enabling a deeper understanding of butanol tolerance and production, progress in these methods, including genome mining, RNA sequencing and constructing of genome scale models are also reviewed. In conclusion, a comparative analysis of both phenomena is presented and a theoretical relationship is described between butanol tolerance/high production and common features including efflux pump formation/activity, stress protein production, membrane modifications and biofilm growth.

Citovat

PATAKOVA, Petra, Jan KOLEK, Karel SEDLAR, Pavlina KOSCOVA, Barbora BRANSKA, Kristyna KUPKOVA, Leona PAULOVA and Ivo PROVAZNÍK. Comparative analysis of high butanol tolerance and production in clostridia. BIOTECHNOLOGY ADVANCES. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2018, vol. 36, No 3, p. 721-738. ISSN 0734-9750. Available from: https://dx.doi.org/10.1016/j.biotechadv.2017.12.004.

@article{1504231,
   author = {Patakova, Petra and Kolek, Jan and Sedlar, Karel and Koscova, Pavlina and Branska, Barbora and Kupkova, Kristyna and Paulova, Leona and Provazník, Ivo},
   article_location = {OXFORD},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.biotechadv.2017.12.004},
   keywords = {Clostridium; ABE fermentation; Butanol tolerance; Butanol production; Genome mining; Transcriptomics},
   language = {eng},
   issn = {0734-9750},
   journal = {BIOTECHNOLOGY ADVANCES},
   title = {Comparative analysis of high butanol tolerance and production in clostridia},
   volume = {36},
   year = {2018}
}

TY  - JOUR
ID  - 1504231
AU  - Patakova, Petra - Kolek, Jan - Sedlar, Karel - Koscova, Pavlina - Branska, Barbora - Kupkova, Kristyna - Paulova, Leona - Provazník, Ivo
PY  - 2018
TI  - Comparative analysis of high butanol tolerance and production in clostridia
JF  - BIOTECHNOLOGY ADVANCES
VL  - 36
IS  - 3
SP  - 721-738
EP  - 721-738
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 07349750
KW  - Clostridium
KW  - ABE fermentation
KW  - Butanol tolerance
KW  - Butanol production
KW  - Genome mining
KW  - Transcriptomics
N2  - 2016, was the 100 years anniversary from launching of the first industrial acetone-butanol-ethanol (ABE) microbial production process. Despite this long period and also revival of scientific interest in this fermentative process over the last 20 years, solventogenic clostridia, mainly Clostridium acetobutylicum, Clostridium beijerinckii, Clostridium saccharoperbutylacetonicum and Clostridium pasteurianum, still have most of their secrets. One such poorly understood mechanism is butanol tolerance, which seems to be one of the most significant bottlenecks obstructing industrial exploitation of the process because the maximum achievable butanol concentration is only about 21 g/L. This review describes all the known cellular responses elicited by butanol, such as modifications of cell membrane and cell wall, formation of stress proteins, extrusion of butanol by efflux pumps, response of regulatory pathways, and also maps both random and targeted mutations resulting in high butanol production phenotypes. As progress in the field is inseparably associated with emerging methods, enabling a deeper understanding of butanol tolerance and production, progress in these methods, including genome mining, RNA sequencing and constructing of genome scale models are also reviewed. In conclusion, a comparative analysis of both phenomena is presented and a theoretical relationship is described between butanol tolerance/high production and common features including efflux pump formation/activity, stress protein production, membrane modifications and biofilm growth.
ER  -

PATAKOVA, Petra, Jan KOLEK, Karel SEDLAR, Pavlina KOSCOVA, Barbora BRANSKA, Kristyna KUPKOVA, Leona PAULOVA and Ivo PROVAZNÍK. Comparative analysis of high butanol tolerance and production in clostridia. \textit{BIOTECHNOLOGY ADVANCES}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2018, vol.~36, No~3, p.~721-738. ISSN~0734-9750. Available from: https://dx.doi.org/10.1016/j.biotechadv.2017.12.004.

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