Genetics of human and animal uncultivable treponemal pathogens

J 2018

Genetics of human and animal uncultivable treponemal pathogens

ŠMAJS, David, Michal STROUHAL and Sascha KNAUF

Basic information

Original name

Genetics of human and animal uncultivable treponemal pathogens

Authors

ŠMAJS, David (203 Czech Republic, guarantor, belonging to the institution), Michal STROUHAL (203 Czech Republic, belonging to the institution) and Sascha KNAUF (276 Germany)

Edition

Infection, Genetics and Evolution, Amsterdam, Elsevier Science, 2018, 1567-1348

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.611

RIV identification code

RIV/00216224:14110/18:00101771

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.meegid.2018.03.015

UT WoS

000432516900014

Keywords in English

Treponema pallidum subsp pallidum; T. pallidum subsp pertenue; T. pallidum subsp endemicum; T. paraluisleporidarum; Non-human primates; Molecular evolution

Abstract

V originále

Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp. endemicum). Several species of nonhuman primates in Africa are infected by treponemes genetically undistinguishable from known human TPE strains. Besides Treponema pallidum, the equally uncultivable Treponema carateum causes pinta in humans. In lagomorphs, Treponema paraluisleporidarum ecovar Cuniculus and ecovar Lepus are the causative agents of rabbit and hare syphilis, respectively. All uncultivable pathogenic treponemes harbor a relatively small chromosome (1.1334-1.1405 Mbp) and show gene synteny with minimal genetic differences (> 98% identity at the DNA level) between subspecies and species. While uncultivable pathogenic treponemes contain a highly conserved core genome, there are a number of highly variable and/or recombinant chromosomal loci. This is also reflected in the occurrence of intrastrain heterogeneity (genetic diversity within an infecting bacterial population). Molecular differences at several different chromosomal loci identified among TPA strains or isolates have been used for molecular typing and the epidemiological characterization of syphilis isolates. This review summarizes genome structure of uncultivable pathogenic treponemes including genetically variable

Links

GA17-25455S, research and development project

Name: Studium genomů patogenních treponem na základě analýzy jednotlivých buněk

Investor: Czech Science Foundation

GJ17-25589Y, research and development project

Name: Kmeny způsobující syfilis: jsou geneticky odlišné kmeny odlišné i v průběhu experimentální infekce?

Investor: Czech Science Foundation

NV17-31333A, research and development project

Name: Vývoj nového typovacího systému pro původce syfilis, Treponema pallidum subsp. pallidum, zaměřeného na proteomické rozdíly

Citovat

ŠMAJS, David, Michal STROUHAL and Sascha KNAUF. Genetics of human and animal uncultivable treponemal pathogens. Infection, Genetics and Evolution. Amsterdam: Elsevier Science, 2018, vol. 61, JUL 2018, p. 92-107. ISSN 1567-1348. Available from: https://dx.doi.org/10.1016/j.meegid.2018.03.015.

@article{1504938,
   author = {Šmajs, David and Strouhal, Michal and Knauf, Sascha},
   article_location = {Amsterdam},
   article_number = {JUL 2018},
   doi = {http://dx.doi.org/10.1016/j.meegid.2018.03.015},
   keywords = {Treponema pallidum subsp pallidum; T. pallidum subsp pertenue; T. pallidum subsp endemicum; T. paraluisleporidarum; Non-human primates; Molecular evolution},
   language = {eng},
   issn = {1567-1348},
   journal = {Infection, Genetics and Evolution},
   title = {Genetics of human and animal uncultivable treponemal pathogens},
   volume = {61},
   year = {2018}
}

TY  - JOUR
ID  - 1504938
AU  - Šmajs, David - Strouhal, Michal - Knauf, Sascha
PY  - 2018
TI  - Genetics of human and animal uncultivable treponemal pathogens
JF  - Infection, Genetics and Evolution
VL  - 61
IS  - JUL 2018
SP  - 92-107
EP  - 92-107
PB  - Elsevier Science
SN  - 15671348
KW  - Treponema pallidum subsp pallidum
KW  - T. pallidum subsp pertenue
KW  - T. pallidum subsp endemicum
KW  - T. paraluisleporidarum
KW  - Non-human primates
KW  - Molecular evolution
N2  - Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp. endemicum). Several species of nonhuman primates in Africa are infected by treponemes genetically undistinguishable from known human TPE strains. Besides Treponema pallidum, the equally uncultivable Treponema carateum causes pinta in humans. In lagomorphs, Treponema paraluisleporidarum ecovar Cuniculus and ecovar Lepus are the causative agents of rabbit and hare syphilis, respectively. All uncultivable pathogenic treponemes harbor a relatively small chromosome (1.1334-1.1405 Mbp) and show gene synteny with minimal genetic differences (> 98% identity at the DNA level) between subspecies and species. While uncultivable pathogenic treponemes contain a highly conserved core genome, there are a number of highly variable and/or recombinant chromosomal loci. This is also reflected in the occurrence of intrastrain heterogeneity (genetic diversity within an infecting bacterial population). Molecular differences at several different chromosomal loci identified among TPA strains or isolates have been used for molecular typing and the epidemiological characterization of syphilis isolates. This review summarizes genome structure of uncultivable pathogenic treponemes including genetically variable
ER  -

ŠMAJS, David, Michal STROUHAL and Sascha KNAUF. Genetics of human and animal uncultivable treponemal pathogens. \textit{Infection, Genetics and Evolution}. Amsterdam: Elsevier Science, 2018, vol.~61, JUL 2018, p.~92-107. ISSN~1567-1348. Available from: https://dx.doi.org/10.1016/j.meegid.2018.03.015.

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