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@article{1504938,
author = {Šmajs, David and Strouhal, Michal and Knauf, Sascha},
article_location = {Amsterdam},
article_number = {JUL 2018},
doi = {http://dx.doi.org/10.1016/j.meegid.2018.03.015},
keywords = {Treponema pallidum subsp pallidum; T. pallidum subsp pertenue; T. pallidum subsp endemicum; T. paraluisleporidarum; Non-human primates; Molecular evolution},
language = {eng},
issn = {1567-1348},
journal = {Infection, Genetics and Evolution},
title = {Genetics of human and animal uncultivable treponemal pathogens},
volume = {61},
year = {2018}
}
TY - JOUR
ID - 1504938
AU - Šmajs, David - Strouhal, Michal - Knauf, Sascha
PY - 2018
TI - Genetics of human and animal uncultivable treponemal pathogens
JF - Infection, Genetics and Evolution
VL - 61
IS - JUL 2018
SP - 92-107
EP - 92-107
PB - Elsevier Science
SN - 15671348
KW - Treponema pallidum subsp pallidum
KW - T. pallidum subsp pertenue
KW - T. pallidum subsp endemicum
KW - T. paraluisleporidarum
KW - Non-human primates
KW - Molecular evolution
N2 - Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp. endemicum). Several species of nonhuman primates in Africa are infected by treponemes genetically undistinguishable from known human TPE strains. Besides Treponema pallidum, the equally uncultivable Treponema carateum causes pinta in humans. In lagomorphs, Treponema paraluisleporidarum ecovar Cuniculus and ecovar Lepus are the causative agents of rabbit and hare syphilis, respectively. All uncultivable pathogenic treponemes harbor a relatively small chromosome (1.1334-1.1405 Mbp) and show gene synteny with minimal genetic differences (> 98% identity at the DNA level) between subspecies and species. While uncultivable pathogenic treponemes contain a highly conserved core genome, there are a number of highly variable and/or recombinant chromosomal loci. This is also reflected in the occurrence of intrastrain heterogeneity (genetic diversity within an infecting bacterial population). Molecular differences at several different chromosomal loci identified among TPA strains or isolates have been used for molecular typing and the epidemiological characterization of syphilis isolates. This review summarizes genome structure of uncultivable pathogenic treponemes including genetically variable
ER -
ŠMAJS, David, Michal STROUHAL and Sascha KNAUF. Genetics of human and animal uncultivable treponemal pathogens. \textit{Infection, Genetics and Evolution}. Amsterdam: Elsevier Science, 2018, vol.~61, JUL 2018, p.~92-107. ISSN~1567-1348. Available from: https://dx.doi.org/10.1016/j.meegid.2018.03.015.
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