FIALA, L., Petr BOB and J. RABOCH. Oncological markers CA-125, CA 19-9 and endometriosis. Medicine. Philadelphia: Lippincott Williams & Wilkins, 2018, vol. 97, No 51, p. 13759-13761. ISSN 0025-7974. Available from: https://dx.doi.org/10.1097/MD.0000000000013759.
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Basic information
Original name Oncological markers CA-125, CA 19-9 and endometriosis
Authors FIALA, L. (203 Czech Republic), Petr BOB (203 Czech Republic, guarantor, belonging to the institution) and J. RABOCH (203 Czech Republic).
Edition Medicine, Philadelphia, Lippincott Williams & Wilkins, 2018, 0025-7974.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30103 Neurosciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.870
RIV identification code RIV/00216224:14740/18:00106589
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1097/MD.0000000000013759
UT WoS 000456334600102
Keywords in English CA 19-9; CA-125; dehydroepiandrosterone sulfate; endometriosis
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 13/3/2019 11:08.
Abstract
The endometrium tissue is functionally androgen related which plays an important role in women's fertility regulation. In addition recent findings show that endometrium related pathology is closely linked to disrupted androgen biosynthesis and associated regulatory functions. These findings also suggest that androgens might play an important role in endometrium related cancer pathology with significant implications for treatment. Based on these findings, we have assessed 50 female outpatients with endometriosis and the clinical investigations were focused on biochemical serum analysis of DHEAS, oncological markers CA-125 and CA 19-9, estradiol, thyreothropic hormone. and prolactin. The results show significant Spearman correlations of CA-125 and CA 19-9 with dehydroepiandrosterone-DHEA-S (R=0.52 resp. R=0.49). This result represents 1st reported finding documenting androgen related increase of CA-125 and CA 19-9 levels as significant markers of endometrium pathology and it is possible to assume that these potential biomarkers could have clinical importance with respect to timely diagnosis.
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