Revitalising the rudimentary replacement dentition in the mouse

POPA, E.M., marcela BUCHTOVÁ and A.S. TUCKER. Revitalising the rudimentary replacement dentition in the mouse. Development. CAMBRIDGE: COMPANY BIOLOGISTS LTD, 2019, vol. 146, No 3, p. 1-11. ISSN 0950-1991. Available from: https://dx.doi.org/10.1242/dev.171363.

Basic information

• Original name: Revitalising the rudimentary replacement dentition in the mouse
• Authors: POPA, E.M. (826 United Kingdom of Great Britain and Northern Ireland), marcela BUCHTOVÁ (203 Czech Republic, guarantor, belonging to the institution) and A.S. TUCKER (826 United Kingdom of Great Britain and Northern Ireland).
• Edition: Development, CAMBRIDGE, COMPANY BIOLOGISTS LTD, 2019, 0950-1991.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10605 Developmental biology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: Full Text
• Impact factor: Impact factor: 5.611
• RIV identification code: RIV/00216224:14310/19:00109295
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1242/dev.171363
• UT WoS: 000458841100014
• Keywords in English: Replacement tooth; Wnt/beta-catenin; Sox2; Mouse molar; Mammal evolution; Minipig
• Tags: rivok
• Tags: International impact, Reviewed

Abstract

Most mammals have two sets of teeth (diphyodont) - a deciduous dentition replaced by a permanent dentition; however, the mouse possesses only one tooth generation (monophyodont). In diphyodonts, the replacement tooth forms on the lingual side of the first tooth from the successional dental lamina. This lamina expresses the stem/progenitor marker Sox2 and has activated Wnt/beta-catenin signalling at its tip. Although the mouse does not replace its teeth, a transient rudimentary successional dental lamina (RSDL) still forms during development. The mouse RSDL houses Sox2-positive cells, but no Wnt/beta-catenin signalling. Here, we show that stabilising Wnt/beta-catenin signalling in the RSDL in the mouse leads to proliferation of the RSDL and formation of lingually positioned teeth. Although Sox2 has been shown to repress Wnt activity, overexpression of Wnts leads to a downregulation of Sox2, suggesting a negative-feedback loop in the tooth. In the mouse, the first tooth represses the formation of the replacement, and isolation of the RSDL is sufficient to induce formation of a new tooth germ. Our data highlight key mechanisms that may have influenced the evolution of replacement teeth. This article has an associated 'The people behind the papers' interview.