SVĚRÁK, Tomáš, Pavla LINHARTOVÁ, Matyáš KUHN, Adéla LÁTALOVÁ, B. BEDNAROVA, Libor USTOHAL and Tomáš KAŠPÁREK. Transcranial magnetic stimulation in borderline personality disorder - case series. Česká a slovenská neurologie a neurochirurgie. Brno: Ambit Media, vol. 82, No 1, p. 48-52. ISSN 1210-7859. doi:10.14735/amcsnn201948. 2019.
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Basic information
Original name Transcranial magnetic stimulation in borderline personality disorder - case series
Name in Czech Transkraniální magnetická stimulace u hraniční poruchy osobnosti – série kazuistik
Authors SVĚRÁK, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Pavla LINHARTOVÁ (203 Czech Republic, belonging to the institution), Matyáš KUHN (203 Czech Republic, belonging to the institution), Adéla LÁTALOVÁ (203 Czech Republic, belonging to the institution), B. BEDNAROVA (203 Czech Republic), Libor USTOHAL (203 Czech Republic, belonging to the institution) and Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution).
Edition Česká a slovenská neurologie a neurochirurgie, Brno, Ambit Media, 2019, 1210-7859.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30103 Neurosciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 0.377
RIV identification code RIV/00216224:14110/19:00108454
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.14735/amcsnn201948
UT WoS 000458015800006
Keywords in English repetitive transcranial magnetic stimulation; rTMS; borderline personality disorder; impulsivity; emotion regulation; Go/NoGo task; neuronavigation
Tags 14110222, CF MAFIL, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 4/3/2020 14:31.
Abstract
We present the results of a case series study of individual ly navigated repetitive transcranial magnetic stimulation (rTMS) in four patients with borderline personality disorder (BPD). Patients and methods: Four patients with BPD performed a Go/NoGo task dur ing functional MRI (fMRI) designed for observ ing behavioural inhibition neural cor relates. The site within the right dorsolateral prefrontal cortex with the largest diff erence in BOLD signal between the NoGo and Go conditions was as signed as a target for rTMS in each patient. Four patients underwent 15 ses sions of individual ly navigated 10-Hz rTMS treatment at 110% of their individual rest ing motor threshold for 3 weeks (one ses sion per work ing day). One ses sion contained 1,500 pulses delivered in 15 trains by 10 s, lead ing to a total of 22,500 pulses dur ing the treatment. Results: The treatment was very well tolerated without any serious side eff ects. After the treatment, the patients reported that they felt better self-control of their emotions, especial ly anger; that their urges for self-harm and suicidal thoughts decreased or disappeared; and that their derealisation/depersonalisation episodes disappeared. Patients also showed less depres sion symp toms after the treatment. Conclusion: rTMS with neuronavigation individualised by a fMRI Go/NoGo task is a promis ing tool for reduc ing impulsive behaviour and enhanc ing emotion regulation in BPD patients. Double-blind placebo-control led studies in larger samples are neces sary to draw further conclusions about rTMS eff ectiveness in BPD.
Links
LM2015062, research and development projectName: Národní infrastruktura pro biologické a medicínské zobrazování
Investor: Ministry of Education, Youth and Sports of the CR
MUNI/A/0976/2017, interní kód MUName: Využití neurozobrazovacích, neurostimulačních a neurofeedbackových metod v psychiatrii (Acronym: IMGTMSNF)
Investor: Masaryk University, Category A
NV15-30062A, research and development projectName: Fenotypy impulzivity u neuropsychiatrických poruch a jejich klinický význam
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