J 2019

Transcranial magnetic stimulation in borderline personality disorder - case series

SVĚRÁK, Tomáš, Pavla LINHARTOVÁ, Matyáš KUHN, Adéla LÁTALOVÁ, B. BEDNAROVA et. al.

Basic information

Original name

Transcranial magnetic stimulation in borderline personality disorder - case series

Name in Czech

Transkraniální magnetická stimulace u hraniční poruchy osobnosti – série kazuistik

Authors

SVĚRÁK, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Pavla LINHARTOVÁ (203 Czech Republic, belonging to the institution), Matyáš KUHN (203 Czech Republic, belonging to the institution), Adéla LÁTALOVÁ (203 Czech Republic, belonging to the institution), B. BEDNAROVA (203 Czech Republic), Libor USTOHAL (203 Czech Republic, belonging to the institution) and Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution)

Edition

Česká a slovenská neurologie a neurochirurgie, Brno, Ambit Media, 2019, 1210-7859

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 0.377

RIV identification code

RIV/00216224:14110/19:00108454

Organization unit

Faculty of Medicine

DOI

UT WoS

000458015800006

Keywords in English

repetitive transcranial magnetic stimulation; rTMS; borderline personality disorder; impulsivity; emotion regulation; Go/NoGo task; neuronavigation

Tags

Tags

International impact, Reviewed
Změněno: 4/3/2020 14:31, Mgr. Pavla Foltynová, Ph.D.

Abstract

V originále

We present the results of a case series study of individual ly navigated repetitive transcranial magnetic stimulation (rTMS) in four patients with borderline personality disorder (BPD). Patients and methods: Four patients with BPD performed a Go/NoGo task dur ing functional MRI (fMRI) designed for observ ing behavioural inhibition neural cor relates. The site within the right dorsolateral prefrontal cortex with the largest diff erence in BOLD signal between the NoGo and Go conditions was as signed as a target for rTMS in each patient. Four patients underwent 15 ses sions of individual ly navigated 10-Hz rTMS treatment at 110% of their individual rest ing motor threshold for 3 weeks (one ses sion per work ing day). One ses sion contained 1,500 pulses delivered in 15 trains by 10 s, lead ing to a total of 22,500 pulses dur ing the treatment. Results: The treatment was very well tolerated without any serious side eff ects. After the treatment, the patients reported that they felt better self-control of their emotions, especial ly anger; that their urges for self-harm and suicidal thoughts decreased or disappeared; and that their derealisation/depersonalisation episodes disappeared. Patients also showed less depres sion symp toms after the treatment. Conclusion: rTMS with neuronavigation individualised by a fMRI Go/NoGo task is a promis ing tool for reduc ing impulsive behaviour and enhanc ing emotion regulation in BPD patients. Double-blind placebo-control led studies in larger samples are neces sary to draw further conclusions about rTMS eff ectiveness in BPD.

Links

LM2015062, research and development project
Name: Národní infrastruktura pro biologické a medicínské zobrazování
Investor: Ministry of Education, Youth and Sports of the CR
MUNI/A/0976/2017, interní kód MU
Name: Využití neurozobrazovacích, neurostimulačních a neurofeedbackových metod v psychiatrii (Acronym: IMGTMSNF)
Investor: Masaryk University, Category A
NV15-30062A, research and development project
Name: Fenotypy impulzivity u neuropsychiatrických poruch a jejich klinický význam