SLABÝ, Ondřej, A. MCDOWELL, H. BRUGGEMANN, A. RAZ, S. DEMIR-DEVIREN, T. FREEMONT, P. LAMBERT and Manu CAPOOR. Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. LAUSANNE: FRONTIERS MEDIA SA, 2018, vol. 8, AUG, p. 272-278. ISSN 2235-2988. Available from: https://dx.doi.org/10.3389/fcimb.2018.00272.
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Basic information
Original name Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris
Authors SLABÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution), A. MCDOWELL (372 Ireland), H. BRUGGEMANN (208 Denmark), A. RAZ (840 United States of America), S. DEMIR-DEVIREN (840 United States of America), T. FREEMONT (826 United Kingdom of Great Britain and Northern Ireland), P. LAMBERT (826 United Kingdom of Great Britain and Northern Ireland) and Manu CAPOOR (840 United States of America, belonging to the institution).
Edition FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, LAUSANNE, FRONTIERS MEDIA SA, 2018, 2235-2988.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.518
RIV identification code RIV/00216224:14740/18:00106680
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.3389/fcimb.2018.00272
UT WoS 000441660900001
Keywords in English Propionibacterium acnes; interleukin-1 beta; nerve growth factor (NGF); degenerative disc disease; acne vulgaris
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 21/3/2019 08:53.
Abstract
The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium Propionibacteriumacnes is now also emerging as a potentially new etiological factor. This human commensal bacterium is well known for its long association with the inflammatory skin condition acne vulgaris. A key component of inflammatory responses to P. acnes in acne appears to be interleukin (IL)-1 beta. Similarly, in degenerative disc disease (DDD) there is compelling evidence for the fundamental roles of IL-1 beta in its pathology. We therefore propose that P. acnes involvement in DDD is biologically very plausible, and that IL-1 beta is the key inflammatory mechanism driving the host response to P. acnes infection. Since there is a solid theoretical basis for this phenomenon, we further propose that the relationship between P. acnes infection and DDD is causal.
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