Is IL-1 beta Further Evidence for the Role of Propionibacterium
acnes in Degenerative Disc Disease? Lessons From the Study of
the Inflammatory Skin Condition Acne Vulgaris

J 2018

Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris

SLABÝ, Ondřej, A. MCDOWELL, H. BRUGGEMANN, A. RAZ, S. DEMIR-DEVIREN et. al.

Basic information

Original name

Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris

Authors

SLABÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution), A. MCDOWELL (372 Ireland), H. BRUGGEMANN (208 Denmark), A. RAZ (840 United States of America), S. DEMIR-DEVIREN (840 United States of America), T. FREEMONT (826 United Kingdom of Great Britain and Northern Ireland), P. LAMBERT (826 United Kingdom of Great Britain and Northern Ireland) and Manu CAPOOR (840 United States of America, belonging to the institution)

Edition

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, LAUSANNE, FRONTIERS MEDIA SA, 2018, 2235-2988

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.518

RIV identification code

RIV/00216224:14740/18:00106680

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.3389/fcimb.2018.00272

UT WoS

000441660900001

Keywords in English

Propionibacterium acnes; interleukin-1 beta; nerve growth factor (NGF); degenerative disc disease; acne vulgaris

Abstract

V originále

The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium Propionibacteriumacnes is now also emerging as a potentially new etiological factor. This human commensal bacterium is well known for its long association with the inflammatory skin condition acne vulgaris. A key component of inflammatory responses to P. acnes in acne appears to be interleukin (IL)-1 beta. Similarly, in degenerative disc disease (DDD) there is compelling evidence for the fundamental roles of IL-1 beta in its pathology. We therefore propose that P. acnes involvement in DDD is biologically very plausible, and that IL-1 beta is the key inflammatory mechanism driving the host response to P. acnes infection. Since there is a solid theoretical basis for this phenomenon, we further propose that the relationship between P. acnes infection and DDD is causal.

Citovat

SLABÝ, Ondřej, A. MCDOWELL, H. BRUGGEMANN, A. RAZ, S. DEMIR-DEVIREN, T. FREEMONT, P. LAMBERT and Manu CAPOOR. Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. LAUSANNE: FRONTIERS MEDIA SA, 2018, vol. 8, AUG, p. 272-278. ISSN 2235-2988. Available from: https://dx.doi.org/10.3389/fcimb.2018.00272.

@article{1508659,
   author = {Slabý, Ondřej and McDowell, A. and Bruggemann, H. and Raz, A. and DemirandDeviren, S. and Freemont, T. and Lambert, P. and Capoor, Manu},
   article_location = {LAUSANNE},
   article_number = {AUG},
   doi = {http://dx.doi.org/10.3389/fcimb.2018.00272},
   keywords = {Propionibacterium acnes; interleukin-1 beta; nerve growth factor (NGF); degenerative disc disease; acne vulgaris},
   language = {eng},
   issn = {2235-2988},
   journal = {FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY},
   title = {Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1508659
AU  - Slabý, Ondřej - McDowell, A. - Bruggemann, H. - Raz, A. - Demir-Deviren, S. - Freemont, T. - Lambert, P. - Capoor, Manu
PY  - 2018
TI  - Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris
JF  - FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
VL  - 8
IS  - AUG
SP  - 272
EP  - 272
PB  - FRONTIERS MEDIA SA
SN  - 22352988
KW  - Propionibacterium acnes
KW  - interleukin-1 beta
KW  - nerve growth factor (NGF)
KW  - degenerative disc disease
KW  - acne vulgaris
N2  - The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium Propionibacteriumacnes is now also emerging as a potentially new etiological factor. This human commensal bacterium is well known for its long association with the inflammatory skin condition acne vulgaris. A key component of inflammatory responses to P. acnes in acne appears to be interleukin (IL)-1 beta. Similarly, in degenerative disc disease (DDD) there is compelling evidence for the fundamental roles of IL-1 beta in its pathology. We therefore propose that P. acnes involvement in DDD is biologically very plausible, and that IL-1 beta is the key inflammatory mechanism driving the host response to P. acnes infection. Since there is a solid theoretical basis for this phenomenon, we further propose that the relationship between P. acnes infection and DDD is causal.
ER  -

SLABÝ, Ondřej, A. MCDOWELL, H. BRUGGEMANN, A. RAZ, S. DEMIR-DEVIREN, T. FREEMONT, P. LAMBERT and Manu CAPOOR. Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris. \textit{FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY}. LAUSANNE: FRONTIERS MEDIA SA, 2018, vol.~8, AUG, p.~272-278. ISSN~2235-2988. Available from: https://dx.doi.org/10.3389/fcimb.2018.00272.

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