Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is
Related to Clinicopathological Features of Gastric Cancer in a
Central European Population

J 2018

Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population

OBERMANNOVA, R., Martina LOJOVÁ, Petra VYCHYTILOVÁ, P. GRELL, W.C. CHO et. al.

Basic information

Original name

Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population

Authors

OBERMANNOVA, R. (203 Czech Republic), Martina LOJOVÁ (203 Czech Republic, belonging to the institution), Petra VYCHYTILOVÁ (203 Czech Republic, belonging to the institution), P. GRELL (203 Czech Republic), W.C. CHO (344 Hong Kong), M. SACHLOVA (203 Czech Republic), M. SVOBODA (203 Czech Republic), R. VYZULA (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Anticancer Research, Athens, International Institute of Anticancer Research, 2018, 0250-7005

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Greece

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.935

RIV identification code

RIV/00216224:14740/18:00106974

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.21873/anticanres.12651

UT WoS

000449934200066

Keywords in English

Gastric cancer; microRNA; diagnosis; prognosis

Abstract

V originále

Background/Aim: In Western countries, most patients with gastric cancer (GC) present in advanced stages. Therefore, there is imminent clinical need for novel diagnostic and prognostic biomarkers. Deregulation of microRNAs has been reported as a frequent event in GC development in a number of studies. Our study validated the potential of microRNAs to serve as diagnostic and prognostic biomarkers in patients with GC from the Central European population. Materials and Methods: Using quantitative real-time polymerase chain reaction, expression levels of six microRNAs (miR-10b, -21, -93, -107, - 143 , and -145) were examined in 67 tumor tissues and 67 paired adjacent gastric tissues, and correlated with clinicopathological features of GC patients. Results: Expression levels of miR-10b, miR-21, miR-93 , and miR-107 were significantly higher in GC samples compared to non-tumor tissue. Furthermore, the expression levels of miR-10b, miR-143, and miR-145 positively correlated with advanced stages, and increased expression of miR-10b, miR-21 and miR-145 was significantly associated with worse prognosis of gastric cancer patients. Conclusion: Our results indicate that selected tissue microRNAs have the potential to serve as relevant diagnostic and prognostic biomarkers of GC in a central European population.

Links

NV17-29389A, research and development project

Name: Sekvenční FDG-PET a miRNA jako biomarker změny strategie předoperační léčby u lokálně pokročilého karcinomu žaludku a gastroesofageální junkce

Citovat

OBERMANNOVA, R., Martina LOJOVÁ, Petra VYCHYTILOVÁ, P. GRELL, W.C. CHO, M. SACHLOVA, M. SVOBODA, R. VYZULA and Ondřej SLABÝ. Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population. Anticancer Research. Athens: International Institute of Anticancer Research, 2018, vol. 38, No 6, p. 3719-3724. ISSN 0250-7005. Available from: https://dx.doi.org/10.21873/anticanres.12651.

@article{1508717,
   author = {Obermannova, R. and Lojová, Martina and Vychytilová, Petra and Grell, P. and Cho, W.C. and Sachlova, M. and Svoboda, M. and Vyzula, R. and Slabý, Ondřej},
   article_location = {Athens},
   article_number = {6},
   doi = {http://dx.doi.org/10.21873/anticanres.12651},
   keywords = {Gastric cancer; microRNA; diagnosis; prognosis},
   language = {eng},
   issn = {0250-7005},
   journal = {Anticancer Research},
   title = {Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population},
   volume = {38},
   year = {2018}
}

TY  - JOUR
ID  - 1508717
AU  - Obermannova, R. - Lojová, Martina - Vychytilová, Petra - Grell, P. - Cho, W.C. - Sachlova, M. - Svoboda, M. - Vyzula, R. - Slabý, Ondřej
PY  - 2018
TI  - Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population
JF  - Anticancer Research
VL  - 38
IS  - 6
SP  - 3719-3724
EP  - 3719-3724
PB  - International Institute of Anticancer Research
SN  - 02507005
KW  - Gastric cancer
KW  - microRNA
KW  - diagnosis
KW  - prognosis
N2  - Background/Aim: In Western countries, most patients with gastric cancer (GC) present in advanced stages. Therefore, there is imminent clinical need for novel diagnostic and prognostic biomarkers. Deregulation of microRNAs has been reported as a frequent event in GC development in a number of studies. Our study validated the potential of microRNAs to serve as diagnostic and prognostic biomarkers in patients with GC from the Central European population. Materials and Methods: Using quantitative real-time polymerase chain reaction, expression levels of six microRNAs (miR-10b, -21, -93, -107, - 143 , and -145) were examined in 67 tumor tissues and 67 paired adjacent gastric tissues, and correlated with clinicopathological features of GC patients. Results: Expression levels of miR-10b, miR-21, miR-93 , and miR-107 were significantly higher in GC samples compared to non-tumor tissue. Furthermore, the expression levels of miR-10b, miR-143, and miR-145 positively correlated with advanced stages, and increased expression of miR-10b, miR-21 and miR-145 was significantly associated with worse prognosis of gastric cancer patients. Conclusion: Our results indicate that selected tissue microRNAs have the potential to serve as relevant diagnostic and prognostic biomarkers of GC in a central European population.
ER  -

OBERMANNOVA, R., Martina LOJOVÁ, Petra VYCHYTILOVÁ, P. GRELL, W.C. CHO, M. SACHLOVA, M. SVOBODA, R. VYZULA and Ondřej SLABÝ. Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population. \textit{Anticancer Research}. Athens: International Institute of Anticancer Research, 2018, vol.~38, No~6, p.~3719-3724. ISSN~0250-7005. Available from: https://dx.doi.org/10.21873/anticanres.12651.

Detailed Information on Publication Record