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@article{1508717,
author = {Obermannova, R. and Lojová, Martina and Vychytilová, Petra and Grell, P. and Cho, W.C. and Sachlova, M. and Svoboda, M. and Vyzula, R. and Slabý, Ondřej},
article_location = {Athens},
article_number = {6},
doi = {http://dx.doi.org/10.21873/anticanres.12651},
keywords = {Gastric cancer; microRNA; diagnosis; prognosis},
language = {eng},
issn = {0250-7005},
journal = {Anticancer Research},
title = {Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population},
volume = {38},
year = {2018}
}
TY - JOUR
ID - 1508717
AU - Obermannova, R. - Lojová, Martina - Vychytilová, Petra - Grell, P. - Cho, W.C. - Sachlova, M. - Svoboda, M. - Vyzula, R. - Slabý, Ondřej
PY - 2018
TI - Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population
JF - Anticancer Research
VL - 38
IS - 6
SP - 3719-3724
EP - 3719-3724
PB - International Institute of Anticancer Research
SN - 02507005
KW - Gastric cancer
KW - microRNA
KW - diagnosis
KW - prognosis
N2 - Background/Aim: In Western countries, most patients with gastric cancer (GC) present in advanced stages. Therefore, there is imminent clinical need for novel diagnostic and prognostic biomarkers. Deregulation of microRNAs has been reported as a frequent event in GC development in a number of studies. Our study validated the potential of microRNAs to serve as diagnostic and prognostic biomarkers in patients with GC from the Central European population. Materials and Methods: Using quantitative real-time polymerase chain reaction, expression levels of six microRNAs (miR-10b, -21, -93, -107, - 143 , and -145) were examined in 67 tumor tissues and 67 paired adjacent gastric tissues, and correlated with clinicopathological features of GC patients. Results: Expression levels of miR-10b, miR-21, miR-93 , and miR-107 were significantly higher in GC samples compared to non-tumor tissue. Furthermore, the expression levels of miR-10b, miR-143, and miR-145 positively correlated with advanced stages, and increased expression of miR-10b, miR-21 and miR-145 was significantly associated with worse prognosis of gastric cancer patients. Conclusion: Our results indicate that selected tissue microRNAs have the potential to serve as relevant diagnostic and prognostic biomarkers of GC in a central European population.
ER -
OBERMANNOVA, R., Martina LOJOVÁ, Petra VYCHYTILOVÁ, P. GRELL, W.C. CHO, M. SACHLOVA, M. SVOBODA, R. VYZULA and Ondřej SLABÝ. Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population. \textit{Anticancer Research}. Athens: International Institute of Anticancer Research, vol.~38, No~6, p.~3719-3724. ISSN~0250-7005. doi:10.21873/anticanres.12651. 2018.
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