Detailed Information on Publication Record
2018
Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population
OBERMANNOVA, R., Martina LOJOVÁ, Petra VYCHYTILOVÁ, P. GRELL, W.C. CHO et. al.Basic information
Original name
Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population
Authors
OBERMANNOVA, R. (203 Czech Republic), Martina LOJOVÁ (203 Czech Republic, belonging to the institution), Petra VYCHYTILOVÁ (203 Czech Republic, belonging to the institution), P. GRELL (203 Czech Republic), W.C. CHO (344 Hong Kong), M. SACHLOVA (203 Czech Republic), M. SVOBODA (203 Czech Republic), R. VYZULA (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Anticancer Research, Athens, International Institute of Anticancer Research, 2018, 0250-7005
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30204 Oncology
Country of publisher
Greece
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.935
RIV identification code
RIV/00216224:14740/18:00106974
Organization unit
Central European Institute of Technology
UT WoS
000449934200066
Keywords in English
Gastric cancer; microRNA; diagnosis; prognosis
Tags
Tags
International impact, Reviewed
Změněno: 21/3/2019 09:41, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
Background/Aim: In Western countries, most patients with gastric cancer (GC) present in advanced stages. Therefore, there is imminent clinical need for novel diagnostic and prognostic biomarkers. Deregulation of microRNAs has been reported as a frequent event in GC development in a number of studies. Our study validated the potential of microRNAs to serve as diagnostic and prognostic biomarkers in patients with GC from the Central European population. Materials and Methods: Using quantitative real-time polymerase chain reaction, expression levels of six microRNAs (miR-10b, -21, -93, -107, - 143 , and -145) were examined in 67 tumor tissues and 67 paired adjacent gastric tissues, and correlated with clinicopathological features of GC patients. Results: Expression levels of miR-10b, miR-21, miR-93 , and miR-107 were significantly higher in GC samples compared to non-tumor tissue. Furthermore, the expression levels of miR-10b, miR-143, and miR-145 positively correlated with advanced stages, and increased expression of miR-10b, miR-21 and miR-145 was significantly associated with worse prognosis of gastric cancer patients. Conclusion: Our results indicate that selected tissue microRNAs have the potential to serve as relevant diagnostic and prognostic biomarkers of GC in a central European population.
Links
| NV17-29389A, research and development project |
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